Mediastinal lymphoma-induced superior vena cava syndrome and chylopericardium in a pregnant lady: A case report

Obeidat, Omar; Baniissa, Bayan; Shkoukani, Zakaria W; Alhouri, Abdullah

doi:10.4103/ajm.ajm_51_19

Cited by 3 publications

(2 citation statements)

References 8 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these 40 cases, there is an equal distribution in the etiology of chylopericardium between tumor-related, idiopathic, and iatrogenic chylopericardium. Of these, only three cases were reported as chylopericardium, presenting as SVC syndrome [8].…”

Section: Discussionmentioning

confidence: 99%

A Rare Occurrence of Chylopericardium in a Case of Anterior Mediastinal Mass

Maheswaran Nair,

Kurian,

Thangakunam

2024

Cureus

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

A Rare Occurrence of Chylopericardium in a Case of Anterior Mediastinal Mass

Maheswaran Nair,

Kurian,

Thangakunam

2024

Cureus

View full text Add to dashboard Cite

“…SVCS is a medical emergency, if not actively treated, the prognosis of SVCS caused by malignant tumors is often poor, and NHL patients tend to have a higher cure rate and a longer survival period [ 8 , 9 ]. At present, glucocorticoids, diuretics, and endovascular treatment are often used to relieve symptoms, while radiotherapy, chemotherapy, combined radiotherapy and chemotherapy, and surgery are used for the final treatment [ 10 , 11 ]. In this study, a retrospective analysis was performed to investigate the efficacy of radiotherapy, chemotherapy, and combined radiotherapy and chemotherapy, as well as comprehensive treatment on SVCS.…”

Section: Introductionmentioning

confidence: 99%

Clinical analysis of 48 cases of malignant superior vena cava syndrome

Sun

Chen

et al. 2021

World J Surg Onc

View full text Add to dashboard Cite

Background The aim of our study was to observe and compare the curative effect of radiotherapy, chemotherapy, and combined radiotherapy and chemotherapy, as well as comprehensive treatment on superior vena cava syndrome (SVCS) caused by malignant etiology. Methods A total of 48 patients with malignant SVCS admitted to our hospital from 2015 to 2020 were selected in this study. According to the different treatment methods, they were divided into radiotherapy group (group 1, 10 cases), chemotherapy group (group 2, 8 cases), combined radiotherapy and chemotherapy group (group 3, 22 cases), and comprehensive treatment group (group 4, 8 cases). Results There were no significant differences in efficacy and side effects among the four groups (all P > 0.05). Group 4 (median survival time of 36 months) could provide longer survival time than groups 1, 2, and 3 (median survival time of 10 months, 13.5 months, and 12 months, respectively). Conclusions For patients with severe symptoms or good prognosis, comprehensive treatment could be selected to improve the quality of life and prolong the survival period; for patients with mild symptoms, radiotherapy, chemotherapy, or combined radiotherapy and chemotherapy could also reduce the symptoms of SVCS and treat tumor lesions.

show abstract

Activation of tyrosine phosphatase PTP1B in pyramidal neurons impairs endocannabinoid signaling by tyrosine receptor kinase trkB and causes schizophrenia-like behaviors in mice

Qin

Zhang

Cruz

et al. 2020

Neuropsychopharmacol.

View full text Add to dashboard Cite

Schizophrenia is a debilitating disorder affecting young adults displaying symptoms of cognitive impairment, anxiety, and early social isolation prior to episodes of auditory hallucinations. Cannabis use has been tied to schizophrenia-like symptoms, indicating that dysregulated endogenous cannabinoid signaling may be causally linked to schizophrenia. Previously, we reported that glutamatergic neuron-selective ablation of Lmo4 , an endogenous inhibitor of the tyrosine phosphatase PTP1B, impairs endocannabinoid (eCB) production from the metabotropic glutamate receptor mGluR5. These Lmo4 -deficient mice display anxiety-like behaviors that are alleviated by local shRNA knockdown or pharmacological inhibition of PTP1B that restores mGluR5-dependent eCB production in the amygdala. Here, we report that these Lmo4 -deficient mice also display schizophrenia-like behaviors: impaired working memory assessed in the Y maze and defective sensory gating by prepulse inhibition of the acoustic startle response. Modulation of inhibitory inputs onto layer 2/3 pyramidal neurons of the prefrontal cortex relies on eCB signaling from the brain-derived neurotrophic factor receptor trkB, rather than mGluR5, and this mechanism was defective in Lmo4 -deficient mice. Genetic ablation of PTP1B in the glutamatergic neurons lacking Lmo4 restored tyrosine phosphorylation of trkB, trkB-mediated eCB signaling, and ameliorated schizophrenia-like behaviors. Pharmacological inhibition of PTP1B with trodusquemine also restored trkB phosphorylation and improved schizophrenia-like behaviors by restoring eCB signaling, since the CB1 receptor antagonist 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl- N -1-piperidinyl-1H-pyrazole-3-carboxamide blocked this effect. Thus, activation of PTP1B in pyramidal neurons contributes to schizophrenia-like behaviors in Lmo4 -deficient mice and genetic or pharmacological intervention targeting PTP1B ameliorates schizophrenia-related deficits.

show abstract

Mediastinal lymphoma-induced superior vena cava syndrome and chylopericardium in a pregnant lady: A case report

Cited by 3 publications

References 8 publications

A Rare Occurrence of Chylopericardium in a Case of Anterior Mediastinal Mass

A Rare Occurrence of Chylopericardium in a Case of Anterior Mediastinal Mass

Clinical analysis of 48 cases of malignant superior vena cava syndrome

Activation of tyrosine phosphatase PTP1B in pyramidal neurons impairs endocannabinoid signaling by tyrosine receptor kinase trkB and causes schizophrenia-like behaviors in mice

Contact Info

Product

Resources

About