Mediastinal liposarcoma in a 30-year-old woman with dyspnea and chest pain

Abstract

Mediastinal liposarcoma (ML) is a rare mesenchymal tumor, accounting for less than 1% of mediastinal tumors. They have a slow growth, so they may not give symptoms for a long time, until the tumor produces compression of close structures. The treatment of choice is surgery, which can be combined with chemo-radiotherapy. We present a case in which the diagnosis of a ML was made in a 30-year-old woman with dyspnea and chest pain.

Successful removal of giant mediastinal lipoma and liposarcoma involving both chest cavities

“…[ 1 – 4 ] However, giant mediastinal lipoma/liposarcoma involving both hemithorax, resulting in the compression of the lung with attendant respiratory embarrassment, is extremely rare in clinic. [ 2 , 3 , 5 ] With good outcomes, surgical removal remains the first choice for the treatment of these kinds of diseases. Nevertheless, the management of a very huge mediastinal tumor involving both chest cavities is always challenging.…”

An unusual case of recurrent huge primary mediastinal dedifferentiated liposarcoma

“…The suspicion arises from CT images which usually showed varied-size mass which combines fat densities with attenuations similar to other soft tissues [ 1 ]. To confirm the diagnosis, clinicians should rule out the dedifferentiated liposarcoma by adequate sampling, cytogenetics, along with immunostaining for MDM2, CDK4, Vimentin or PPAR gamma [ 5 ].…”

“…It mostly found in lower limbs and retroperitoneum. Mediastinal liposarcoma (ML) is an extremely rare entity, accounting for about 1% of all mediastinal tumors, predominantly in posterior part, and less than 2% of all liposarcomas [ 1 ]. Dedifferentiated liposarcoma is the least common subtype of liposarcoma, particularly found in male over the fourth decades [ 2 ] and appear to be challenging to diagnose.…”

“…Most patients present with dyspnea, chest discomfort or cough. Patients may also present with superior vena cava syndrome [ 2 ] Most similar reported cases were successfully treated by complete surgical excision alone [ 1 , 2 ], but in this case, after removal of the giant tumor, it recurred 6 months later and leading for a need of chemotherapy.…”

"Incidental Discovery of Dedifferentiated Liposarcoma of the Anterior Mediastinum: A Case Report"

“…Liposarcomas are common soft-tissue neoplasms accounting for 20% of mesenchymal malignancies [1]. Mediastinal occurrence is rare, accounting for only 2% of all liposarcomas and less than 1% of mediastinal tumors [2,3]. 85% of mediastinal liposarcomas present with mass effect symptoms, such as shortness of breath, arrhythmias, and hoarseness [4].…”