Mediastinal Histoplasmosis With Esophageal Perforation Presenting as Recurrent Polymicrobial Empyema and Pericarditis in a Previously Healthy Child

Madigan, Theresa; Fattahi, Sayeh; Rajapakse, Nipunie; Ristagno, Elizabeth H.

doi:10.1093/jpids/piz042

Cited by 1 publication

(3 citation statements)

References 13 publications

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“…It is well established in adult and paediatric literature that histoplasma pericarditis has shown to usually be accompanied by mediastinal lymphadenopathy, pneumonia or pleural effusion 3 7–9. Isolated single organ infection as in our index patient is rare 7.…”

Section: Discussionmentioning

confidence: 65%

“…Histoplasma pericarditis is rare, and it has been reported to occur in 6% of patients with acute histoplasmosis 3 5 6 8 9. It is mediated by an inflammatory or a host immune response rather than an infective reaction and occurs as a complication of mediastinal lymphadenitis in patients with acute pulmonary histoplasmosis.…”

Section: Discussionmentioning

confidence: 99%

“…Amphotericin is recommended for moderate to severe cases of progressive disseminated histoplasma infections. 2 9…”

Section: Discussionmentioning

confidence: 99%

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Histoplasma associated pericarditis with pericardial tamponade in a child

Jawahar,

Thattaliyath,

Badheka

et al. 2023

BMJ Case Rep

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Histoplasma-mediated pericarditis is rare, and it occurs due to host-mediated inflammatory or immune response to adjacent mediastinal adenitis or pneumonitis. It is usually self-limited and rarely progresses to a disseminated infection in an immunocompetent individual. In rare instances, it can occur without pulmonary manifestations, making the diagnosis challenging given the broad list of differentials that can be considered as in our patient who initially presented with an isolated pericardial effusion with tamponade needing emergent pericardiocentesis.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%