Mediastinal hibernoma simulates a malignant lesion on dual time point FDG imaging

Burdick, Michael J.; Jolles, Paul Rudolf; Grimes, Margaret M.; Henry, Danielle

doi:10.1016/j.lungcan.2007.08.020

Cited by 14 publications

(12 citation statements)

References 25 publications

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“…Little is known regarding the imaging of hibernomas on 18 F FDG-PET scans. The reported high FDG accumulation in these fat-containing tumors may be attributed to the metabolically active cellular elements rather than reflect their malignant or not potential [28,29]. …”

Section: Discussionmentioning

confidence: 99%

Imaging of hibernomas: A retrospective study on twelve cases

et al. 2011

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BackgroundTo analyze the imaging features of hibernomas on computed tomography (CT) and magnetic resonance (MRI).MethodsTwelve hibernomas were retrospectively assessed with CT and MR imaging and compared to the histology of the specimenResultsNine females and three males with a mean age of 30 years were included. Ten tumors occurred in the thigh and two affected the subcutis of the periscapular and buttock regions. On eight CT scans, seven (87,5%) lesions were homogeneous and mildly to moderately hyperdense compared to subcutaneous fat while one lesion was heterogeneous with mixed hypo and hyperattenuating areas. On six T1W images, five (83,3%) lesions appeared homogeneous and hypointense relative to subcutaneous fat and one was heterogeneous. Incomplete fat suppression was depicted in all cases. All lesions displayed marked enhancement. Large intratumoral vessels were depicted in three of the 12 (25%) cases. Septations were depicted on four of the eight unenhanced CT and on all six MRI examinations.ConclusionsHibernoma usually appears hypodense and hypointense relative to subcutaneous fat on pre-contrast CT and MR T1W with variable enhancement patterns and incomplete fat suppression on STIR or fat-saturated sequences. These characteristics relate directly to the presence of brown fat. However, atypical findings such as heterogeneous patterns of mixed fatty and non fatty components on unenhanced CT and MR T1W can be also encountered. Absence of large intratumoral vessels should not exclude hibernomas from the differential diagnosis of regional lipomatous tumors.

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Section: Discussionmentioning

confidence: 99%

Imaging of hibernomas: A retrospective study on twelve cases

et al. 2011

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“…However, DTPI in benign disease has been rarely reported, [9] and it may show a better description of metabolic status and extent of benign infectious disease than early (at 1 h after administration of FDG) imaging. To the best of our knowledge, this is the first report on using DTPI in patients with cerebral sparganosis and tuberculous meningitis (TBM).…”

Section: Introductionmentioning

confidence: 99%

Experience of Dual Time Point Brain F-18 FDG PET/CT Imaging in Patients with Infectious Disease

Kim

Park

et al. 2010

Nucl Med Mol Imaging

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Dual time point FDG PET imaging (DTPI) has been considered helpful for discrimination of benign and malignant disease, and staging lymph node status in patients with pulmonary malignancy. However, DTPI for benign disease has been rarely reported, and it may show a better description of metabolic status and extent of benign infectious disease than early imaging only. The authors report on the use F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) imaging with additional delayed imaging on a 52-year-old man with sparganosis and a 70-year-old man with tuberculous meningitis. To the best of our knowledge, this is the first report on dual time point PET/CT imaging in patients with cerebral sparganosis and tuberculous meningitis.

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“…CT-PET findings of hibernoma are indistinguishable from malignancy, often leading to a false-positive interpretation. Biopsy is required to exclude a malignant aetiology [10][11][12][13]. To our knowledge, this is the first case of a mammary hibernoma being imaged by CT-PET.…”

Section: Discussionmentioning

confidence: 94%

An unusual breast lesion: the ultrasonographic, mammographic, MRI and nuclear medicine findings of mammary hibernoma

Martini¹,

Londero²,

Machin³

et al. 2010

BJR

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We report the case of a 42-year-old woman being treated for an ovarian cancer who was diagnosed at the age of 40. A CT-positron emission tomography (PET) scan performed as follow-up documented abnormal uptake in the right breast. Mammograms were negative for malignancy, while a focal hyperechoic lesion was observed on ultrasonography in the same breast. Thus, she was referred to our institution for breast MRI, which showed a focal area of enhancement with atypical features. Percutaneous biopsy was performed, and a mammary hibernoma was diagnosed. Radiological and pathological correlation was provided. To our knowledge, this is the only report that describes the features of this rare tumour on four different imaging modalities (mammography, ultrasonography, MRI and CT-PET).

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Mediastinal hibernoma simulates a malignant lesion on dual time point FDG imaging

Cited by 14 publications

References 25 publications

Imaging of hibernomas: A retrospective study on twelve cases

Imaging of hibernomas: A retrospective study on twelve cases

Experience of Dual Time Point Brain F-18 FDG PET/CT Imaging in Patients with Infectious Disease

An unusual breast lesion: the ultrasonographic, mammographic, MRI and nuclear medicine findings of mammary hibernoma

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