Mediastinal hamartoma - A rare presentation

Balakrishnan, Jayaprakash; Maniyan, Deepu; Nayak, Nileena; Nair, Anila Kunjulekshmi Amma Raveendran

doi:10.4103/0970-2113.168111

Cited by 3 publications

(4 citation statements)

References 2 publications

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“…The most common localization of hamartoma is lung tissue. The mediastinal hamartoma is quite rare, in either the posterior or the anterior part [5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Mediastinal Cartilaginous Hamartoma

Vuckovic¹,

Koledin²,

Vuckovic

et al. 2020

Cureus

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Pulmonary hamartomas are usually solitary, nodular benign lesions in the parenchyma of the lung. They are rarely situated in endobronchial areas, and very few cases are reported with the mediastinum. A 56-year-old female patient got a CT-scan conducted due to coughing and breathlessness and was diagnosed with a nodular lesion in the medial mediastinum. The lesion was operated: it measured up to 4 cm in the largest diameter, had a smooth surface, was of rather soft but elastic consistency, and was extirpated. At pathology, on cut section, it was yellowish and lobular, and with a mixture of cartilaginous, fibrous and adipose tissues with some smooth muscle cell fibers and myxoid areas. The diagnosis of pulmonary hamartoma was made with atypical medial mediastinal localization. This rare presentation could pose some differential diagnostic problems in the clinical diagnosis of more frequent primary and metastatic malignant diseases.

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“…The most common localization of hamartoma is lung tissue. The mediastinal hamartoma is quite rare, in either the posterior or the anterior part [5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Mediastinal Cartilaginous Hamartoma

Vuckovic¹,

Koledin²,

Vuckovic

et al. 2020

Cureus

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“…Pulmonary hamartomas (PH) are benign neoplasms developed from peribronchial mesenchyme representing 8% of all pulmonary neoplasms. 1 Hamartoma occurring in the mediastinum is extremely rare and only few cases have been reported. 1 , 2 They typically present in middle-aged males, are usually asymptomatic, and radiologically and histologically heterogeneous.…”

mentioning

confidence: 99%

“… 1 , 2 They typically present in middle-aged males, are usually asymptomatic, and radiologically and histologically heterogeneous. 1 , 3 Mediastinal hamartomas are generally large and show a broad radiological differential diagnosis, which include malignancies, so histopathological examination should be performed 2 and needle aspiration can be appropriate in determining the diagnosis. 1 , 2 , 3 , 4 , 5 …”

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confidence: 99%

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Mediastinal Hamartoma Diagnosed by Endobronchial Ultrasound Guided Transbronchial Needle Aspiration

Royo

Mitjà

2022

Open Respiratory Archives

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Clinical, Radiologic, and Pathologic Characteristics of Pulmonary Hamartomas With Uncommon Presentation

Chatzopoulos

Johnson

Boland

2020

American Journal of Clinical Pathology

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Objectives To investigate the clinicopathologic and radiologic features of pulmonary hamartomas (PHs) with uncommon clinical presentation. Methods A retrospective clinicopathologic and radiologic review was performed for patients diagnosed (1999-2019) with multiple hamartomas, lesions arising adjacent to a coexisting pulmonary malignancy, and tumors with predominantly extrapulmonary localization. Results Of 979 patients diagnosed with PHs, 6 (0.6%) had multiple hamartomas, 4 (0.4%) had hamartomas adjacent to lung adenocarcinoma, and 2 (0.2%) had large mediastinal masses. Patients with multiple lesions had a median age of 65 years and mean tumor size of 0.9 cm; 1 patient had 3 hamartomas, and 5 patients had 2. Lesions next to adenocarcinomas had a mean size of 1.4 cm, and affected patients had a median age of 69 years. Predominantly mediastinal PHs, diagnosed in a 63-year-old woman and a 68-year-old man, measured 4.1 to 6 cm and were connected to the lung. All lesions were solid on imaging with absence of definitive fat or calcification, concerning for granuloma or malignancy. All cases had typical histology of PH, although one of the mediastinal tumors had an unusual amount of epithelial hyperplasia. Conclusions PHs can be clinically and radiologically challenging to diagnose. Histopathologic examination of biopsies and resection specimens is diagnostically crucial in this setting.

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Mediastinal hamartoma - A rare presentation

Cited by 3 publications

References 2 publications

Mediastinal Cartilaginous Hamartoma

Mediastinal Cartilaginous Hamartoma

Mediastinal Hamartoma Diagnosed by Endobronchial Ultrasound Guided Transbronchial Needle Aspiration

Clinical, Radiologic, and Pathologic Characteristics of Pulmonary Hamartomas With Uncommon Presentation

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