Mediastinal germ cell tumour during the COVID-19 pandemic

O'Brien, Timothy; Power, Derek G.

doi:10.1136/bcr-2020-237003

Cited by 1 publication

(1 citation statement)

References 4 publications

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“…MGCTs occur more frequently in patients with Klinefelter syndrome 29. Notably, MGCT was recently reported in a patient initially suspected to have COVID-19 presenting with respiratory symptoms 30…”

Section: Clinical Featuresmentioning

confidence: 99%

Mediastinal Germ Cell Tumors: A Review and Update on Pathologic, Clinical, and Molecular Features

El-Zaatari

2021

Advances in Anatomic Pathology

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Mediastinal germ cell tumors (MGCTs) are the most common extragonadal germ cell tumors (GCTs) and most often arise in the anterior mediastinum with a male predilection. MGCTs also have a predilection for patients with Klinefelter syndrome and possibly other genetic conditions. MGCTs, as GCTs at other extragonadal sites, are thought to arise from germ cells improperly retained during migration along the midline during embryogenesis. Similar to their counterparts in the testes, MGCTs are classified into seminomatous and nonseminomatous GCTs. Seminomatous MGCT represents pure seminoma, whereas nonseminomatous MGCTs encompass pure yolk sac tumors, embryonal carcinoma, choriocarcinoma, mature or immature teratoma, and mixed GCTs with any combination of GCT types, including seminoma. Somatictype or hematologic malignancies can also occur in association with a primary MGCT. MGCTs share molecular findings with GCTs at other sites, most commonly the presence of chromosome 12p gains and isochromosome i(12p). Treatment includes neoadjuvant chemotherapy followed by surgical resection of residual tumor, with the exception of benign teratomas, which require only surgical resection without chemotherapy. In this review, we highlight and provide an update on pathologic, clinical, and molecular features of MGCTs. Immunohistochemical profiles of each tumor type, as well as differential diagnostic considerations, are discussed.

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Section: Clinical Featuresmentioning

confidence: 99%

Mediastinal Germ Cell Tumors: A Review and Update on Pathologic, Clinical, and Molecular Features

El-Zaatari

2021

Advances in Anatomic Pathology

View full text Add to dashboard Cite

show abstract

Mediastinal germ cell tumour during the COVID-19 pandemic

Cited by 1 publication

References 4 publications

Mediastinal Germ Cell Tumors: A Review and Update on Pathologic, Clinical, and Molecular Features

Mediastinal Germ Cell Tumors: A Review and Update on Pathologic, Clinical, and Molecular Features

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