Mediastinal and pulmonary entomophthoromycosis with superior vena cava syndrome: case report

Filiio, João Carlos Coelho; Pereira, Jorge Luís Gavina; Júnior, Álvaro Rabello

doi:10.1590/s0036-46651989000600010

Cited by 9 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 are comparable to the zygospores developed by C. incongruus in culture. Similarly, Coelho-Filho (178) and Marwaha et al (179) also reported systemic cases caused by putative Conidiobolus species involving the superior vena cava without culture. However, entomophthoralean fungi rarely invade blood vessels, and the pathological features of the observed slender hyphae are not typical of these fungi, so the possibility of infection caused by P. insidiosum has to be taken into consideration (114).…”

Section: Clinical Features Of Entomophthoramycosis Conidiobolomycosismentioning

confidence: 93%

Human Pathogenic Entomophthorales

Vilela

Mendoza

2018

Clin Microbiol Rev

View full text Add to dashboard Cite

SUMMARYThe pathogenic entomophthoralean fungi cause infection in insects and mammalian hosts. and species can be found in soil and insect, reptile, and amphibian droppings in tropical and subtropical areas. The life cycles of these fungi occur in these environments where infecting sticky conidia are developed. The infection is acquired by insect bite or contact with contaminated environments through open skin. typically causes chronic rhinofacial disease in immunocompetent hosts, whereas some species can be found in immunocompromised patients. infection is restricted to subcutaneous tissues but may be involved in intestinal and disseminated infections. Its early diagnosis remains challenging due to clinical similarities to other intestinal diseases. Infected tissues characteristically display eosinophilic granulomas with the Splendore-Höeppli phenomenon. However, in immunocompromised patients, the above-mentioned inflammatory reaction is absent. Laboratory diagnosis includes wet mount, culture serological assays, and molecular methodologies. The management of entomophthoralean fungi relies on traditional antifungal therapies, such as potassium iodide (KI), amphotericin B, itraconazole, and ketoconazole, and surgery. These species are intrinsically resistant to some antifungals, prompting physicians to experiment with combinations of therapies. Research is needed to investigate the immunology of entomophthoralean fungi in infected hosts. The absence of an animal model and lack of funding severely limit research on these fungi.

show abstract

Section: Clinical Features Of Entomophthoramycosis Conidiobolomycosismentioning

confidence: 93%