Median Nerve Affection in Hypertensive Patients with and without Diabetes High-Resolution Ultrasound Assessment

Abstract

Purpose Diabetes is a documented risk factor for peripheral neuropathy. It was reported that associated hypertension could increase this risk. The present study aimed to assess the effect of hypertension and diabetes on median nerve using high-resolution ultrasound. Methods The study includes 50 hypertensive patients (HTN group), 50 diabetic patients (DM group), 50 patients with coexisting diabetes and hypertension (HTN + DM group) and 50 healthy controls. Median nerve affection in the studied groups was studied by vibration perception thresholds (VPT). The median nerve cross-sectional area was determined at the nerve cross-sectional area of the median nerve at the carpal tunnel by high-resolution ultrasound. Clinical symptoms were assessed using Toronto Clinical Severity Score (TCSS). Results There was significantly higher median nerve CSA in all patient groups in comparison to controls. HTN + DM group had significantly higher median nerve CSA when compared with DM group. Patients with peripheral neuropathy in HTN + DM and DM groups had significantly higher median nerve CSA than patients without. Using ROC curve analysis, it was shown that median CSA could successfully distinguish patients with peripheral neuropathy from patients without in HTN + DM group [AUC (95% CI): 0.71 (0.54–0.89)] and in DM group [AUC (95% CI): 0.86 (0.72–0.99)]. Conclusion Hypertensive patients with and without diabetes have significantly higher median nerve CSA when compared with controls.

A Cross-Sectional Study on Motor and Sensory Nerve Functions in Women Newly Diagnosed and Untreated for Hypothyroidism in a Tribal Area of Odisha, India

“…For this study we used a convenience sample with fixed inclusion and exclusion criteria. Adult female patients belonging to the tribal community aged between 18 and 60 years, who were diagnosed with hypothyroidism and not yet initiated on any treatment, and did not suffer from diabetes, hypertension (12) or neuromuscular disorders (such as muscle hypertrophy, carpal tunnel syndrome, amyotrophic lateral sclerosis, Guillain-Barré syndrome, Lambert-Eaton myasthenic syndrome, diabetic neuropathy) were included after obtaining written consent from each of the selected subjects. Exclusion criteria encompassed individuals with acute or chronic diseases, those under medication affecting nerve conductions like calcium or methylcobalamin, individuals with vitamin B12 deficiency or undergoing treatment with methylcobalamin, those with a history of smoking (13) or alcohol consumption, and women in any trimester of pregnancy.…”