Medialization Laryngoplasty With Gore-Tex: An Animal Study

Comparison of Lyophilized Glutaraldehyde-Preserved Bovine Pericardium with Different Vascular Prostheses for Use as Vocal Cords Implants: Experimental Study

“…In this study, treatment with 0.5% glutaraldehyde was used because concentrations below 0.1% reduce to resistance to collagenases [ 13 , 22 – 24 , 27 , 28 ]. This coincides with the findings described by other authors [ 5 , 6 ], who mentioned that the use of bovine collagen for VC medialization has a lower absorption rate than other materials. However, our results do not agree with those of Lee et al [ 2 ] and Shiotani et al [ 29 ], who report that bovine collagen is rapidly degraded; we found well-structured collagen fibers three months after implantation.…”

“…This is consistent with reports by de Souza et al [ 3 ], Zhang et al [ 26 ], and Ruijgrok et al [ 27 ], who have studied the use of different materials as implants. Moreover, the reduced inflammatory response observed in the VC that were implanted with LGPBP occurred because this is a biologically inert material, which, unlike the synthetics, is less porous, more flexible, and has more tissue-like characteristics; therefore, it produces less foreign body reaction, as described by other authors who have used different synthetic materials for medialization [ 3 , 5 , 6 ]. The extrusion of the implant observed in the VC that were treated with TF was due to the synthetic material causing a severe chronic granulomatous reaction in which an abscess and fistula were formed, through which the implant was ejected [ 3 , 21 ].…”

“…These fibers undergo changes in the primary amines of the lysine and hydroxyproline residues and form inter- and intramolecular cross-links in their chains after being treated with glutaraldehyde [ 21 – 24 ], which improves their biochemical stability (allowing the elastic and collagen fibers to remain well-organized), improves their resistance, allows them to retain their shape, and increases their stiffness [ 9 , 12 , 13 ]. In contrast, synthetic materials tend to curl at the edges because they are formed by rigid amorphous fibers that maintain their memory [ 5 , 6 , 25 ].…”

“…However, our results do not agree with those of Lee et al [ 2 ] and Shiotani et al [ 29 ], who report that bovine collagen is rapidly degraded; we found well-structured collagen fibers three months after implantation. Synthetic materials were not absorbed because their microporous structure allows the growth of connective tissue without inflammation similar to that which has been observed in vascular and cardiac implants, preventing their absorption [ 6 , 19 , 20 ]. However, the VC that were medialized with TF in the dogs that reached the end of the study showed severe chronic inflammation due to the structure being less porous and having a rough surface.…”

Safety and Efficacy of Cosmetic Augmentation of the Nasal Tip and Nasal Dorsum With Expanded Polytetrafluoroethylene

“…Several animal models and clinical experience have confirmed the high biocompatibility and safety of ePTFE. [14][15][16][17] Minimal chronic inflammation and foreign-body reaction were observed in those studies. A tiny fibrotic capsule forms around the implant.…”