Medial septal lesions, radial arm maze performance, and sympathetic sprouting: a study of recovery of function

Crutcher, Keith A.; Kesner, Raymond P.; Novak, Jeanne M.

doi:10.1016/0006-8993(83)90472-9

Cited by 62 publications

(19 citation statements)

References 20 publications

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“…The first studies to address this issue were reported by Kimble et al (1979aKimble et al ( , 1979bKimble et al ( , 1979cKimble et al ( , 1980 who failed to find any significant contribution of sympathetic ingrowth on the recovery of spontaneous alternation, maze learning, conditioned taste aversion and open-field activity scores after lesions of the dorsal hippocampus. Crutcher et al (1983) have reported similar conclusions in rats tested in a radial-maze learning task after lesions of the MS. These findings, however, are at variance with more recent reports in which sympathetic ingrowth into the cholinergically denervated hippocampus was found to have some influence upon the postsurgical behavioral recovery.…”

Section: Reactive Compensations and Behavioral Correlatessupporting

confidence: 66%

The Fimbria-Fornix/Cingular Bundle Pathways: A Review of Neurochemical and Behavioural Approaches Using Lesions and Transplantation Techniques

Cassel

Duconseille

Jeltsch

et al. 1997

Progress in Neurobiology

104

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Section: Reactive Compensations and Behavioral Correlatessupporting

confidence: 66%

The Fimbria-Fornix/Cingular Bundle Pathways: A Review of Neurochemical and Behavioural Approaches Using Lesions and Transplantation Techniques

Cassel

Duconseille

Jeltsch

et al. 1997

Progress in Neurobiology

104

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“…However, if se vere and long-lasting spatial cognitive deficit after MCA occlusion is 'mainly due to the hippocampal damage, the levels of ACh in the hippocampus should be affected. Crutcher et al (1983) suggested that an impairment of the radial-arm maze perfor mance after medial septal lesions usually disappears within 3 weeks if the cholinergic denervation is not perfect «90%). In addition, a 50% loss of hippo campal choline acetyItransferase (ChAT) activity caused a spatial cognitive deficit only when a delay interval was imposed on the radial maze task (Chrobak et aI., 1988).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Spatial Cognitive Impairment after Middle Cerebral Artery Occlusion in Rats: No Involvement of the Hippocampus

Okada

Nakanishi

Tamura

et al. 1995

J Cereb Blood Flow Metab

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Summary:The behavioral and neurochemical changes in the chronic phase of permanent occlusion of the right middle cerebral artery (MCA) in rats were investigated. One month after MCA occlusion, 23 rats were unable to solve a radial eight-arm maze task during an entire I-month period, whereas seven rats were able to solve this task. Three months after occlusion, 19 MCA-oc cluded rats failed to solve the task successfully again for at least I month (the cognitively impaired rats), whereas II MCA-occluded rats were able to solve it (the cogni tively unimpaired rats). The rats that underwent behav ioral testing were examined for any changes in the ace tylcholine (ACh) levels in the hippocampus using HPLC with electrochemical detection or the formation of long term potentiation (L TP) in the population spike of the hippocampal CAl field. The immunohistochemical distriPermanent unilateral middle cerebral artery (MCA) occlusion in rats is widely used as a model of focal cerebral ischemia. In the acute phase, this model selectively causes infarction in the ipsilateral cerebral cortex and caudate nucleus-putamen com plex (Tamura et aI., 1981 a; lizuka et aI., 1989). Af ter the infarction in the territory of the MCA, �2 weeks after MCA occlusion, progressive shrinkage occurs in the ipsilateral thalamus (Fujie et aI., 1990) Received March 31, 1994; final revision received October 14, 1995; accepted February 27, 1995. Address correspondence and reprint requests to Dr. Michihiro Fujiwara, Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-01, Japan.Abbreviations used: MeA, middle cerebral artery; LTP, long term potentiation; MAP2, microtubule-associated protein 2; GFAP, glial fibrillary acidic protein. 1012bution of either the microtubule-associated protein 2 (MAP2) or glial fibrillary acidic protein (GF AP) in the hippocampus of the cognitively impaired rats was also studied. In the cognitively impaired rats, neither the sup pression of the induction of L TP, nor the degradation of MAP2, nor the increase in the GFAP immunoreactivity was observed in the hippocampus. The levels of ACh in the hippocampus did not change significantly among the cognitively impaired, unimpaired, and the sham-operated rats. These results suggest that MCA occlusion is capable of producing long-term spatial cognitive disturbance in rats without any evidence of neurobiological damage in the hippocampus. Key Words: Focal cerebral ischemia Memory-Long-term potentiation-Microtubule-asso ciated protein 2-Glial fibrillary acidic protein.

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“…Concerning the functional involvement of sympathetic ingrowth, a major part of the investigations has been focused on the behavioral effects of this phenomenon in rats with either septal or fimbria-fornix lesions. From these investigations it is known that, under some conditions and in a manner that seems to depend closely on the animal's gender, sympathetic ingrowth may produce either detrimental or beneficial effects on the cognitive deficits induced by the lesions ( see, e.g ., Chafez et al ., 1982 ;Crutcher et al ., 1983 ;Harrell et al ., 1983 ;Harrell and Parsons, 1988 ;Ayyagari et al ., 1991 ) . Thus, as concerns behavior, sympathetic ingrowth might also be of clinical interest because, on the one hand, recent evidence has shown its occurrence in the hippocampus of patients with Alzheimer's disease (Booze et al ., 1993) and, on the other hand, Leanza et al .…”

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confidence: 99%

Sympathetic Sprouting: Time Course of Changes of Noradrenergic, Cholinergic, and Serotonergic Markers in the Denervated Rat Hippocampus

Jackisch¹,

Neufang²,

Hertting³

et al. 1995

Journal of Neurochemistry

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As a first step for experiments investigating the presynaptic characteristics of sympathetic fibers grown into the denervated hippocampus, we studied the time course of changes of neurochemical markers in the rat hippocampus, subsequent to aspiration lesions of the fimbria‐fornix and the overlying callosal and cortical structures. At various postsurgical delays (1, 2, 8, 24, and 40 weeks), the activity of choline acetyltransferase, the high‐affinity synaptosomal uptake of choline and noradrenaline, and the concentrations of noradrenaline, serotonin, and 5‐hydroxyindoleacetic acid were measured in a dorsal, an intermediate, and a ventral part of the hippocampus. Levels of all markers were significantly reduced shortly (1–2 weeks) after the lesions. However, whereas the cholinergic (choline uptake and choline acetyltransferase activity) and the serotonergic (concentrations of serotonin and 5‐hydroxyindoleacetic acid) markers remained significantly reduced for up to 40 weeks, both noradrenergic markers recovered to near‐normal (noradrenaline uptake) or even supranormal (noradrenaline concentration) levels, although with clear‐cut differences in the time course and the regional characteristics. The noradrenaline content reached control levels already 8 weeks after lesion surgery and was about two to three times higher 40 weeks later, with the most dramatic effects in the ventral hippocampus. In contrast, high‐affinity noradrenaline uptake reached control values only 24 weeks after lesion and exceeded them only in the ventral hippocampus 40 weeks after surgery. It is concluded (a) that hippocampal noradrenaline concentration is a more sensitive marker for sympathetic sprouting than high‐affinity noradrenaline uptake and (b) that functional in vitro studies on hippocampal sympathetic ingrowth appear to fit optimal conditions in the ventral hippocampus at a delay of at least 40 weeks after surgery.

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Medial septal lesions, radial arm maze performance, and sympathetic sprouting: a study of recovery of function

Cited by 62 publications

References 20 publications

The Fimbria-Fornix/Cingular Bundle Pathways: A Review of Neurochemical and Behavioural Approaches Using Lesions and Transplantation Techniques

The Fimbria-Fornix/Cingular Bundle Pathways: A Review of Neurochemical and Behavioural Approaches Using Lesions and Transplantation Techniques

Long-Term Spatial Cognitive Impairment after Middle Cerebral Artery Occlusion in Rats: No Involvement of the Hippocampus

Sympathetic Sprouting: Time Course of Changes of Noradrenergic, Cholinergic, and Serotonergic Markers in the Denervated Rat Hippocampus

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