Medial Prefrontal Cortical Cannabinoid CB1 Receptors Mediate Morphine–Dextromethorphan Cross State-Dependent Memory: The Involvement of BDNF/cFOS Signaling Pathways

Ghasemzadeh, Zahra; Rezayof, Ameneh

doi:10.1016/j.neuroscience.2018.10.012

Cited by 10 publications

(3 citation statements)

References 82 publications

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“…Our hypothesis is that the activation of ERK in the NAc represents a neuronal response related to the contextual memory of the rewarding effect of morphine and is thereby associated with long‐lasting neuroadaptation in morphine addiction. Although it has been reported that memory impairment caused by chronic morphine is associated with the functional disturbance of molecules involved in memory pathways, 48 further mechanisms remain to be studied.…”

Section: Discussionmentioning

confidence: 99%

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Dual‐specificity phosphatase 15 (DUSP15) in the nucleus accumbens is a novel negative regulator of morphine‐associated contextual memory

et al. 2020

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Section: Discussionmentioning

confidence: 99%

“…Although it has been reported that memory impairment caused by chronic morphine is associated with the functional disturbance of molecules involved in memory pathways, 48 further mechanisms remain to be studied.…”

Section: Methodsmentioning

confidence: 99%

Dual‐specificity phosphatase 15 (DUSP15) in the nucleus accumbens is a novel negative regulator of morphine‐associated contextual memory

et al. 2020

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“…Functional interactions between opioid and cannabinoid systems in rewarding and analgesic effects have also been demonstrated in several biochemical, molecular, and pharmacological studies (9,10). Cannabinoid receptor type 1 (CB1R) and MORs have been found in the same presynaptic nerve terminals with shared signaling pathways through a common receptor-mediated G-protein pathway (11,12).…”

Section: Introductionmentioning

confidence: 96%

Increases in Pro-inflammatory Cytokines in the Ventral Striatum Following Frequent Morphine Exposure Impose New Setpoints in the Expression of Biologically-Relevant Genes to Addiction and Neuroinflammation in Rats

Ahmadi

Khanizad

Fotouhi

2022

Jentashapir J Cell Mol Biol

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Background: The ventral striatum is an integrated drug reward and addiction center. Objectives: We aimed to examine changes in pro-inflammatory cytokines and subsequent changes in the expression of biologically relevant genes to addiction and neuroinflammation in the ventral striatum in response to frequent morphine exposure. Methods: Sixteen male Wistar rats were divided into two experimental groups, a control, and a morphine-treated group, receiving eight days of twice-daily injections of either saline or morphine sulfate (10 mg/kg). Results: The results revealed that frequent morphine treatment increased both gene and protein levels of pro-inflammatory cytokines, including tumor necrosis factor α, interleukin 1-β, and interleukin 6 in the ventral striatum. Frequent morphine treatment also induced significant upregulations in the mRNA levels of mu-opioid receptor, dopamine D1 receptor (Drd1), Fos, nuclear factor- kappa B, and pre-miRNAs expression including, mir-124, mir-133b, mir-339, mir-365, and Let-7c1 in the ventral striatum. On the contrary, frequent morphine injection significantly downregulated mRNA levels of toll-like receptor 4, cannabinoid CB1 and CB2 receptors, Drd2, Il1r, Il6r, tnfr, protein kinase Cγ, calcium/calmodulin-dependent protein kinase IIα, nitric oxide synthase, cAMP-response element-binding protein as well as p38 and Jnk3 MAP kinases in the ventral striatum. However, no group differences were detected in the expression of Erk1 and mir-219 in the ventral striatum. Conclusions: It can be concluded that dysregulations in pro-inflammatory cytokines and, subsequently, in the downstream signaling pathways impair physiological functions of the ventral striatum following chronic morphine exposure, affecting reward pathways and the expression of morphine tolerance and dependence.

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Cross state-dependent memory retrieval between morphine and norharmane in the mouse dorsal hippocampus

Ebrahimi-Ghiri

Khakpai

Zarrindast

2019

Brain Research Bulletin

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Medial Prefrontal Cortical Cannabinoid CB1 Receptors Mediate Morphine–Dextromethorphan Cross State-Dependent Memory: The Involvement of BDNF/cFOS Signaling Pathways

Cited by 10 publications

References 82 publications

Dual‐specificity phosphatase 15 (DUSP15) in the nucleus accumbens is a novel negative regulator of morphine‐associated contextual memory

Dual‐specificity phosphatase 15 (DUSP15) in the nucleus accumbens is a novel negative regulator of morphine‐associated contextual memory

Increases in Pro-inflammatory Cytokines in the Ventral Striatum Following Frequent Morphine Exposure Impose New Setpoints in the Expression of Biologically-Relevant Genes to Addiction and Neuroinflammation in Rats

Cross state-dependent memory retrieval between morphine and norharmane in the mouse dorsal hippocampus

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