Medial prefrontal cortex suppression of the hypothalamic–pituitary–adrenal axis response to a physical stressor, systemic delivery of interleukin‐1β

Crane, James W.; Ebner, Karl; Day, Trevor A.

doi:10.1046/j.1460-9568.2003.02568.x

Cited by 41 publications

(37 citation statements)

References 36 publications

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“…volving PL and IL augmented the response to physiological but not emotional stressors (Crane et al, 2003). Despite providing limited details of lesion placement and extent, these studies offered some basis for inferring a dorsoventral distinction in mPFC control, as was observed in the present study.…”

Section: Discussionmentioning

confidence: 51%

“…7) is lacking, the idea that local GABAergic neurons provide a relay through which mPFC influences are exerted on the stress axes (Roland and Sawchenko, 1993;Herman et al, 2003Herman et al, , 2005) is consistent with evidence that extrinsic mPFC projections are overwhelmingly excitatory (glutamatergic) (Ottersen et al, 1995), although its influence on HPA activation is predominantly inhibitory (Diorio et al, 1993;Brake et al, 2000;Figueiredo et al, 2003;Spencer et al, 2005). It should also be noted that evidence has been provided for a facilitatory influence of IL on HPA output mediated via the bed nucleus of the stria terminalis (Crane et al, 2003;Choi et al, 2004), which may be germane to the attenuated HPA response profile we observe after mPFCv lesions.…”

Section: Discussionmentioning

confidence: 68%

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Regional Differentiation of the Medial Prefrontal Cortex in Regulating Adaptive Responses to Acute Emotional Stress

Radley¹,

Arias²,

Sawchenko³

2006

J. Neurosci.

402

279

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The medial prefrontal cortex (mPFC) is an important neural substrate for integrating cognitive-affective information and regulating the hypothalamo-pituitary-adrenal (HPA) axis response to emotional stress. mPFC modulation of stress responses is effected in part via the paraventricular hypothalamic nucleus (PVH), which houses both autonomic (sympathoadrenal) and neuroendocrine (HPA) effector mechanisms. Although the weight of evidence suggests that mPFC influences on stress-related PVH outputs are inhibitory, discordant findings have been reported, and such work has tended to treat this cortical region as a unitary structure. Here we compared the effects of lesions of the dorsal versus ventral aspects of mPFC, centered in the prelimbic and infralimbic fields, respectively, on acute restraint stress-induced activation of PVH cell groups mediating autonomic and neuroendocrine responses. Lesions to the dorsal mPFC enhanced restraint-induced Fos and corticotropin-releasing factor (CRF) mRNA expression in the neurosecretory region of PVH. Ablation of the ventral mPFC decreased stress-induced Fos protein and CRF mRNA expression in this compartment but increased Fos induction in PVH regions involved in central autonomic control. Repetition of the experiments in rats bearing retrograde tracer deposits to label PVHautonomic projections confirmed that ventral mPFC lesions selectively increased stress-induced Fos expression in identified preautonomic neurons. Finally, hormonal indices of HPA activation in response to acute stress were augmented after dorsal mPFC lesions and attenuated after ventral mPFC lesions. These results suggest that dorsal and ventral aspects of the mPFC differentially regulate neuroendocrine and autonomic PVH outputs in response to emotional stress.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 68%

Regional Differentiation of the Medial Prefrontal Cortex in Regulating Adaptive Responses to Acute Emotional Stress

Radley¹,

Arias²,

Sawchenko³

2006

J. Neurosci.

402

279

View full text Add to dashboard Cite

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“…This circuitry has been most widely implicated as being engaged in emotional stress paradigms (Roland and Sawchenko, 1993;Herman et al, 2002), but recent evidence from lesion studies supports a restraining role of the medial prefrontal cortex in the HPA response to an i.v. IL-1 challenge (Crane et al, 2003).…”

Section: Central Processing Of Seb-related Signalsmentioning

confidence: 99%

CNS activational responses to staphylococcal enterotoxin B: T-lymphocyte-dependent immune challenge effects on stress-related circuitry

Serrats

Sawchenko

2006

J. Comp. Neurol.

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Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that engages the immune system in a T-lymphocyte-dependent manner and induces a cytokine profile distinct from that elicited by the better-studied bacterial pathogen analog, lipopolysaccharide (LPS). Because of reports of SEB recruiting central nervous system (CNS) host defense mechanisms via pathways in common with LPS, we sought to further characterize central systems impacted by this agent. Rats were treated with SEB at doses of 50-5,000 mug/kg, and killed 0.5-6 hours thereafter. SEB injection produced a discrete pattern of Fos induction in brain that peaked at 2-3 hours postinjection and whose strength was dose-related. Induced Fos expression was predominantly subcortical and focused in a set of interconnected central autonomic structures, including aspects of the bed n. of the stria terminalis, central amygdala and lateral parabrachial nuclei; functionally related (and LPS-responsive) cell groups in the n. solitary tract, ventrolateral medulla, and paraventricular hypothalamic n. (PVH) were, by contrast, weakly responsive. SEB also activated cell groups in the limbic forebrain (lateral septal n, medial prefrontal cortex) and hypothalamic GABAergic neurons, which could account for its failure to elicit reliable increases in Fos-ir or corticotropin-releasing factor (CRF) mRNA in the PVH. SEB nevertheless did provoke reliable pituitary-adrenal secretory responses. The identification of subsets of central autonomic and limbic forebrain structures that are sensitive to SEB provides a basis for a systems-level understanding of the physiological and behavioral effects attributed to the superantigen. Core SEB-responsive cell groups exclude a medullary-PVH circuit implicated in pituitary-adrenal responses to LPS.

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“…The mPFC plays a role in reward processing and goal-directed behavior in animals (Wise, 2000) and in humans (Rogers et al, 2004) and exerts significant control over the emotional-cognitive aspect of behavior (Vertes, 2004). Neuroanatomical studies in animals have shown that the mPFC has reciprocal connections with several nuclei of the amygdala (Ongur and Price, 2000), thalamus, and brainstem (Vertes, 2004) and relates with hormonal response to stress through the hypothalamic-pituitary-adrenal axis (Crane et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

A Variant C178T in the Regulatory Region of the Serotonin Receptor GeneHTR3AModulates Neural Activation in the Human Amygdala

Iidaka¹,

Ozaki²,

Matsumoto³

et al. 2005

J. Neurosci.

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Converging evidence in neurophysiological and neuroimaging studies has suggested that the limbic and prefrontal systems play important roles in emotion and cognition. These structures are activated when we see a human face, assuming that we automatically evaluate the biological significance of the stimuli. The serotonin (5-HT) system within the brain has been tied to various behaviors such as mood and anxiety and to the biology of neuropsychiatric disorders. To investigate the link between the 5-HT system and limbic/prefrontal activity, normal subjects (n ϭ 26) who underwent functional magnetic resonance imaging and faced recognition tasks were genotyped for the single nucleotide polymorphism C178T in the regulatory region of the serotonin receptor type 3 gene (HTR3A). We found that the subjects with C/C alleles had greater activity in the amygdala and dorsal and medial prefrontal cortices than those with C/T alleles. The C/C group also showed a faster reaction time during the task than the C/T group. The temperamental predisposition of the subjects had a significant correlation with brain activity in the C/C group. The genotype effect in the right amygdala and prefrontal cortex was largest during the first run of the experiment. These results indicate that the C178T variation in the HTR3A has a critical influence on the amygdaloid activity and on human face processing, probably through regulation of the receptor expression. The present study may contribute to elucidating a possible link among genes, the brain, and behavior in normal populations and may help reveal the biological basis of neuropsychiatric disorders.

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Medial prefrontal cortex suppression of the hypothalamic–pituitary–adrenal axis response to a physical stressor, systemic delivery of interleukin‐1β

Cited by 41 publications

References 36 publications

Regional Differentiation of the Medial Prefrontal Cortex in Regulating Adaptive Responses to Acute Emotional Stress

Regional Differentiation of the Medial Prefrontal Cortex in Regulating Adaptive Responses to Acute Emotional Stress

CNS activational responses to staphylococcal enterotoxin B: T-lymphocyte-dependent immune challenge effects on stress-related circuitry

A Variant C178T in the Regulatory Region of the Serotonin Receptor GeneHTR3AModulates Neural Activation in the Human Amygdala

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