Medial prefrontal cortex suppresses reward-seeking behavior with risk of punishment by reducing sensitivity to reward
Monami Nishio,
Masashi Kondo,
Eriko Yoshida
et al.
Abstract:Reward-seeking behavior is frequently associated with risk of punishment. There are two types of punishment: positive punishment, which is defined as addition of an aversive stimulus, and negative punishment, involves the omission of a rewarding outcome. Although the medial prefrontal cortex (mPFC) is important in avoiding punishment, whether it is important for avoiding both positive and negative punishment and how it contributes to such avoidance are not clear. In this study, we trained male mice to perform … Show more
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