Medial prefrontal cortex supports perceptual memory

Schwiedrzik, Caspar M.; Sudmann, Sandrin S.; Thesen, Thomas; Wang, Xiuyuan; Groppe, David M.; Mégevand, Pierre; Doyle, Werner; Mehta, Ashesh D.; Devinsky, Orrin; Melloni, Lucía

doi:10.1016/j.cub.2018.07.066

Cited by 24 publications

(20 citation statements)

References 12 publications

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“…The role of the dmPFC in the representation of events in memory continues as memories are stored. The dmPFC aids in the stabilization of visual percepts in memory over short periods of time (Schwiedrzik et al, 2018), and it continues to play a role in their stabilization over longer-term periods. For instance, when memories are cued over periods of slow-wave sleep-a phase of sleep linked to the consolidation of memories-this leads to strengthened connectivity between the dmPFC and occipital regions (Berkers et al, 2018).…”

Section: Examples Of Dmpfc Engagementmentioning

confidence: 99%

Guiding the Emotion in Emotional Memories: The Role of the Dorsomedial Prefrontal Cortex

Kensinger

Ford

2021

Curr Dir Psychol Sci

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Models of episodic emotional memory typically concern why emotional events are more likely to be remembered than neutral events, focusing on interactions between the amygdala and other medial temporal lobe regions. But memories of emotional events can be distinguished by their affective tone and framing. We propose that the dorsomedial prefrontal cortex (dmPFC), a region that is increasingly recognized to crosscut socio-affective and cognitive domains, plays a key role in this aspect of emotional memory. After briefly reviewing the role of the dmPFC in the control of behaviors ranging from actions to emotions to social cognition, we delve into the accumulating evidence that its functions also subserve the abstraction of meaning from events and the control of memories, particularly emotional memories. Its role begins during the encoding of emotional experiences, continues through their stabilization, and endures during the retrieval of memory content. At each phase, the dmPFC participates in the integration of affective and cognitive components of memories, setting up networks and framings that either emphasize or de-emphasize emotional content. Incorporating the dmPFC into models of episodic emotional memory should provide leverage in understanding the affective tone with which experiences are brought to memory.

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Section: Examples Of Dmpfc Engagementmentioning

confidence: 99%

Guiding the Emotion in Emotional Memories: The Role of the Dorsomedial Prefrontal Cortex

Kensinger

Ford

2021

Curr Dir Psychol Sci

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“…The medial frontal gyrus (MedFG) is part of the medial prefrontal cortex, which is considered to manage the perceptual memory, the extinction of learned fear, and executive function (Kim et al, 2009;Schwiedrzik et al, 2018). Volumetric changes in the MedFG have been reported in adjustment disorder, schizophrenia, and major depression disorder research (Inoue et al, 2012;Frascarelli et al, 2015;Myung et al, 2016;Belleau et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Gray Matter Volume and Functional Connectivity in Hypochondriasis: A Magnetic Resonance Imaging and Support Vector Machine Analysis

Shen

Zhao

et al. 2020

Front. Hum. Neurosci.

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Objective: Patients with hypochondriasis hold unexplainable beliefs and a fear of having a lethal disease, with poor compliances and treatment response to psychotropic drugs. Although several studies have demonstrated that patients with hypochondriasis demonstrate abnormalities in brain structure and function, gray matter volume (GMV) and functional connectivity (FC) in hypochondriasis still remain unclear.Methods: The present study collected T1-weighted and resting-state functional magnetic resonance images from 21 hypochondriasis patients and 22 well-matched healthy controls (HCs). We first analyzed the difference in the GMV between the two groups. We then used the regions showing a difference in GMV between two groups as seeds to perform functional connectivity (FC) analysis. Finally, a support vector machine (SVM) was applied to the imaging data to distinguish hypochondriasis patients from HCs.Results: Compared with the HCs, the hypochondriasis group showed decreased GMV in the left precuneus, and increased GMV in the left medial frontal gyrus. FC analyses revealed decreased FC between the left medial frontal gyrus and cuneus, and between the left precuneus and cuneus. A combination of both GMV and FC in the left precuneus, medial frontal gyrus, and cuneus was able to discriminate the hypochondriasis patients from HCs with a sensitivity of 0.98, specificity of 0.93, and accuracy of 0.95.Conclusion: Our study suggests that smaller left precuneus volumes and decreased FC between the left precuneus and cuneus seem to play an important role of hypochondriasis. Future studies are needed to confirm whether this finding is generalizable to patients with hypochondriasis.

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“…When it came to self-awareness and self-re ection under a resting state, DNM was activated. Additionally, the region works in the cognitive process, regulating emotion, and sociability [27]. Medial prefrontal gyrus lesions were found to result in relatively short-term incontinence in adults.…”

Section: Regional Nodal Metricsmentioning

confidence: 99%

Brain responses to strong desire to void with synchronous urodynamics in healthy adults: a functional magnetic resonance imaging study based on graph theory

Ying¹,

Gao²,

Liu³

2021

Preprint

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Background The alternations of brain responses to strong desire to void during a urodynamic study were unclear. The present study aims to identify the functional brain network's topologic property changes evoked by a strong desire to void in healthy male and female adults with synchronous urodynamics using a graph theory analysis. Methods The bladders of eleven healthy males and eleven females were filled with a catheter in a specific infusion and withdrawal pattern. The resting-state functional magnetic resonance imaging (fMRI) of the enrolled subjects was scanned under the empty bladder and strong desire to void states. Automated anatomical labeling (AAL) atlas was used to identify the ninety cortical and subcortical regions. Pearson's correlation calculations were performed to establish a brain connection matrix. A paired t-test (P < 0.05) and Bonferroni correction were applied to identify the significant statistical differences in topologic properties between the two states, including small-world network property parameters [gamma (γ) and lambda (λ)], characteristic path length (Lp), clustering coefficient (Cp), global efficiency (Eglob), local efficiency (Eloc) and regional nodal efficiency (Enodal). Results Significantly, a small-world network property was presented in all subjects. The significantly decreased Cp, Lp, Eloc, and increased Eglob were detected in the female subjects under the strong desire to void. Notably, the increased Enodal was observed in left the orbital part of middle frontal gyrus and inferior frontal gyrus, right middle temporal gyrus, median cingulate and middle occipital gyrus, and bilateral inferior parietal gyrus, gyrus rectus and supramarginal gyrus. In the male subjects, the increased Enodal presented in right frontal operculum and medial superior frontal gyrus, left supplementary motor area and the bilateral supramarginal gyrus. On the other hand, the significant decreased Enodal in female subjects was detected in the bilateral calcarine fissure and surrounding cortex, lingual gyrus, and fusiform gyrus. The decreased Enodal in male subjects presented in right inferior occipital gyrus and thalamus. Conclusions In the study, there were potential gender differences in functional brain network's topologic property alternations in response to the strong desire to void under a repetitive infusion and withdrawal pattern.

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Medial prefrontal cortex supports perceptual memory

Cited by 24 publications

References 12 publications

Guiding the Emotion in Emotional Memories: The Role of the Dorsomedial Prefrontal Cortex

Guiding the Emotion in Emotional Memories: The Role of the Dorsomedial Prefrontal Cortex

Gray Matter Volume and Functional Connectivity in Hypochondriasis: A Magnetic Resonance Imaging and Support Vector Machine Analysis

Brain responses to strong desire to void with synchronous urodynamics in healthy adults: a functional magnetic resonance imaging study based on graph theory

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