Medial prefrontal cortex lesions inhibit reflex micturition in anethetized rats

Matsumoto, Seiji; Hanai, Tadashi; Yoshioka, Nobuhiro; Shimizu, Nobuyoshi; Sugiyama, Takahide; Uemura, Hirotsugu

doi:10.1016/j.neures.2005.09.005

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…Besides, lesioning the medial prefrontal cortex would prolong the time interval between volume-evoked bladder contractions without changing the amplitude of contractions [29]. Our bladder dysfunction data was consistent with these previous studies.…”

Section: Discussionsupporting

confidence: 92%

Long-Lasting Exendin-4-Loaded PLGA Nanoparticles Ameliorate Cerebral Ischemia/Reperfusion Evoked Brain Injury and Voiding Dysfunction in Diabetic Rats

Chung

Cheng

et al. 2021

Preprint

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Exendin-4 (Ex-4) is an incretin mimetic agent approved for diabetes treatment and neuronal protection. However, the required frequent injections restrict its clinical application. We prepared Ex-4-loaded poly(d,l-lactide-co-glycolide) nanoparticles (PEx-4) and investigated the effect on cerebral ischemia/reperfusion (IR) injury associated with cystopathy in diabetic rats. Using ten minutes of bilateral carotid artery occlusion combined with hemorrhage-induced hypotension of IR model in streptozotocin-induced type 1 diabetic (T1DM) Wistar rats, we compared Ex-4 and PEx-4 effect on prefrontal cortex edema, voiding function and oxidative stress including cerebral spinal fluid (CSF) reference H2O2 (RH2O2) and HOCl (RHOCl) levels, endoplasmic reticulum (ER) stress, apoptosis, autophagy and pyroptosis signaling in brain and bladder by western blot and immunohistochemistry. Single injection of PEx-4 displayed higher CSF antioxidant activity and long-lasting hypoglycemic effect than Ex-4 in rats. T1DM enhanced CSF RH2O2, and pIRE-1/cleaved caspase-12/pJNK/ATF4/ATF6/CHOP-mediated ER stress, caspase 3/PARP mediated apoptosis, Beclin-1/LC3-II mediated autophagy and caspase 1/IL-1β mediated pyroptosis signaling in the prefrontal cortex and bladders. IR led to prefrontal cortex edema, impairment in micturition center and further increased CSF RH2O2 and HOCl level, ER stress, apoptosis, autophagy and pyroptosis signaling in the T1DM brains and bladders. PEx-4 were more efficient than Ex-4 in attenuating IR-evoked prefrontal cortex edema and oxidative stress in brains and improving voiding dysfunction in bladders of T1DM rats. In summary, PEx-4 with stronger antioxidant activity and long-lasting bioavailability confer efficiently therapeutic efficacy to ameliorate IR-evoked brain and bladder injury through inhibiting oxidative stress, ER stress, apoptosis, autophagy and pyroptosis signaling in diabetic rats.

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Section: Discussionsupporting

confidence: 92%

Long-Lasting Exendin-4-Loaded PLGA Nanoparticles Ameliorate Cerebral Ischemia/Reperfusion Evoked Brain Injury and Voiding Dysfunction in Diabetic Rats

Chung

Cheng

et al. 2021

Preprint

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“…However, our study indicates that the anterior cingulate gyrus is strongly associated with the FDV. Although the exact role of this region is not fully understood, recent animal experiments using anesthetized rats also supported the notion that the medial prefrontal cortex participates in the control of micturition and urinary continence 22 …”

Section: Discussionmentioning

confidence: 92%

“…Although the exact role of this region is not fully understood , recent animal experiments using anesthetized rats also supported the notion that the medial prefrontal cortex participates in the control of micturition and urinary continence. 22 The cingulate gyrus and parahippocampal gyrus are components of the limbic system, which maintains human homeostasis related to the endocrine system and autonomic nervous system. Moreover, the limbic system is thought to be associated with emotional memory.…”

Section: Discussionmentioning

confidence: 99%

Brain responses during the first desire to void: A positron emission tomography study

Takao¹,

Tsujimura²,

Miyagawa³

et al. 2008

Int J of Urology

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Objectives: First desire to void (FDV) is defined as the first feeling that would lead the patient to pass urine. The aim of the present study is to identify the brain regions activated during FDV. Methods: Six healthy right-handed male volunteers, aged 31-40 years, agreed to participate in this study. Rather than inserting a urethral catheter, we used a urinary volume monitoring unit and a self-adhesive external condom catheter for this study. Positron emission tomography (PET) scans obtained in the FDV and post-voiding (absence of urge to void) (REST) states were analyzed and compared. Results: First desire to void state was associated with increased blood flow in the right and left cerebellum, right parahippocampal gyrus (Brodmann area [BA] 30), left superior frontal gyrus (BA9), and left cingulate gyrus (BA32). Rest state was associated with decreased blood flow in the right superior temporal gyrus (BA22), right uncus (BA28), right cingulate gyrus (BA32), left middle temporal gyrus (BA21), and left medial frontal gyrus (BA25). According to region of interest analysis, regional cerebral blood flow of the periaqueductal grey and pons was significantly increased at FDV as opposed to REST. Conclusions: We located possible brain activity associated with the FDV sensation. Combined activation of the right and left cerebellum, parahippocampal gyrus, superior frontal gyrus, and left cingulate gyrus could be associated with FDV.

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“…In anesthetized rats, lesioning of the mPFC inhibits reflex micturition, affecting the timing but not the amplitude of bladder contractions (Matsumoto et al . ). All these observations confirm the importance of the mPFC in the control of voiding, but how it is achieved and where precisely the decision to void is made is not yet clear.…”

Section: The Brain–bladder Networkmentioning

confidence: 97%

The micturition switch and its forebrain influences

Griffiths

Fowler

2012

Acta Physiologica

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Dr DeGroat and Wickens has reviewed the central neural mechanisms controlling the lower urinary tract with a major focus on the brain stem circuitry that mediates the switch-like characteristics of micturition, in particular the periaqueductal grey and the pontine micturition centre (de 2012). The review culminates in a computer model of how the brainstem switch operates in animals in which forebrain influences on micturition have been removed by decerebration. In this complementary paper, we review the mechanisms of forebrain involvement in the voluntary control of human micturition and the maintenance of continence with evidence based heavily on the results of functional brain imaging experiments.

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Medial prefrontal cortex lesions inhibit reflex micturition in anethetized rats

Cited by 9 publications

References 23 publications

Long-Lasting Exendin-4-Loaded PLGA Nanoparticles Ameliorate Cerebral Ischemia/Reperfusion Evoked Brain Injury and Voiding Dysfunction in Diabetic Rats

Long-Lasting Exendin-4-Loaded PLGA Nanoparticles Ameliorate Cerebral Ischemia/Reperfusion Evoked Brain Injury and Voiding Dysfunction in Diabetic Rats

Brain responses during the first desire to void: A positron emission tomography study

The micturition switch and its forebrain influences

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