Medial plantar and dorsal sural nerve conduction studies increase the sensitivity in the detection of neuropathy in diabetic patients

Uluç, Kayıhan; İşak, Barış; Borucu, Deniz; Temuçin, Çağrı Mesut; Çetinkaya, Yılmaz; Koytak, Pınar Kahraman; Tanridag, Tulin; Us, Önder

doi:10.1016/j.clinph.2008.01.001

Cited by 60 publications

(40 citation statements)

References 15 publications

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“…Kökoğlu et al detected a slowing in DS NCV in the patient group compared to the control group in early-stage diabetic neuropathy [11]. Uluç et al found significantly lower amplitudes and conduction velocities of DS and MP sensory nerve responses in patients with diabetic sensory neuropathy and normal routine electrophysiological studies [12]. Our results were in agreement with that study, although our patients had no symptoms suggestive sensory neuropathy.…”

Section: Discussionsupporting

confidence: 83%

A Study of Distal Sensory Nerves in Patients with Newly Diagnosed Asymptomatic Type 2 DM

Ay¹

2016

Eu Clin Anal Med

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Our study enrolled a total of 35 Type II Diabetes patients (20 females, 15 males) with a mean age of 47.22±8.15 years, and 30 healthy controls (17 females and 13 males) with a mean age of 49.30±6.56 years. The two groups did not significantly differ with respect to age and sex (p>0.05). MP, MDC, and DS sensory nerve conduction studies, performed additionally to the standard PNP protocol, revealed that the amplitudes and conduction velocities of each of the three nerves were significantly lower than those of the control group (p<0.01). Discussion: It is possible to diagnose diabetic PNP at an early, asymptomatic stage by studying sensory nerves conduction properties of MP, MDC, and DS in addition to the standard electrophysiological PNP protocol. Detection of PNP by these methods at an early stage may help taking measures to prevent progression into symptomatic PNP.

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Section: Discussionsupporting

confidence: 83%

A Study of Distal Sensory Nerves in Patients with Newly Diagnosed Asymptomatic Type 2 DM

Ay¹

2016

Eu Clin Anal Med

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“…8 In fact, frank DM may be the final stage of a deranged glucose regulation, preceded by a sustained impaired glucose tolerance; in this sort of a pathophysiological continuum, nerve function may be damaged early on, above all in small fibres (Ratzmann et al, 1991;Novella et al, 2001;Singleton et al, 2001;Sumner et al, 2003). Then, the progression of the neuropathy seems to be quite slow as suggested by Lehtinen et al's (1993) 5-year follow-up study.…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological Evaluation of Peripheral and Autonomic Neuropathy in Patients With Newly Diagnosed Diabetes

Gopi¹,

Jagadeesh²

2018

jebmh

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BACKGROUNDIndia has one of the highest prevalence of T2DM in the world. It is estimated that by the year 2030 there are will be nearly 80 million Indians with T2DM in the country. Although neuropathy is an extensively studied complication in patients with DM; however, the neuropathy risk in pre-diabetes and in newly diagnosed diabetes has not been well characterized.The aim and objective of the study is assess and characterize the early electrophysiological signs of peripheral neuropathy and to evaluate the prevalence autonomic neuropathy in diabetic patients at diagnosis in comparison with controls.

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“…All subjects underwent conventional NCS, including left ulnar motor and sensory nerve with bilateral posterior tibial and common peroneal motor nerves, using standard techniques as previously described [26] . In addition, bilateral sural nerve, DS nerve, medial dorsal cutaneous (MDC) nerve of the superficial peroneal sensory nerve and MP sensory NCS were performed according to the previously described methods [23,24,27] . Sural, DS and MDC nerves were studied antidromically; MP sensory nerve action potential (SNAP) was recorded orthodromically.…”

Section: Nerve Conduction Studiesmentioning

confidence: 99%

“…However, this may not be adequate to judge the more distal and thin nerve fibers especially in the early disease course, due to the dying back mechanism in DPN. Several studies have declared that the dorsal sural (DS), medial plantar (MP) nerve and interdigital NCS of the foot yield more sensitive results for detecting DPN at early stages [22][23][24] .…”

Section: Introductionmentioning

confidence: 99%

Association between the Levels of IL-6, sE-Selectin and Distal Sensory Nerve Conduction Studies in Patients with Prediabetes

et al. 2016

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Aim: To determine the association between interleukin-6 (IL-6) and soluble E-selectin (sE-selectin) levels with the electrodiagnostic abnormalities in patients with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). Methods: Serum HbA1c, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, IL-6 and sE-selectin levels were analyzed in 25 IFG patients, 22 IGT patients and 41 controls. Nerve conduction studies (NCS) of sural, dorsal sural (DS), medial dorsal cutaneous and medial plantar sensory nerves were conducted. Results: HbA1c and IL-6 levels were significantly higher in IFG and IGT patients than the controls. IGT patients had higher sE-selectin levels compared to controls and IFG patients. IL-6 levels were significantly correlated with levels of CRP, fibrinogen, ESR and sE-selectin in patients with prediabetes. Both IFG and IGT patients had substantial impairments in very distal sensory NCS. IL-6 levels were positively correlated with HbA1c and negatively correlated with DS NCS in prediabetic patients. Conclusions: Inflammation and endothelial dysfunction might be important in patients with IFG or IGT. Furthermore, our findings strengthen the idea that inflammation (increased levels of IL-6) might be associated with early electrophysiological impairments in patients with prediabetes. NCS of the most distal sensory nerves significantly enhanced the diagnosis of subclinical neuropathy in patients with prediabetes. Subclinical peripheral sensory neuropathy should be investigated in prediabetes to lower the number of future outcomes they are associated with.

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Medial plantar and dorsal sural nerve conduction studies increase the sensitivity in the detection of neuropathy in diabetic patients

Cited by 60 publications

References 15 publications

A Study of Distal Sensory Nerves in Patients with Newly Diagnosed Asymptomatic Type 2 DM

A Study of Distal Sensory Nerves in Patients with Newly Diagnosed Asymptomatic Type 2 DM

Electrophysiological Evaluation of Peripheral and Autonomic Neuropathy in Patients With Newly Diagnosed Diabetes

Association between the Levels of IL-6, sE-Selectin and Distal Sensory Nerve Conduction Studies in Patients with Prediabetes

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