Medial amygdalar tau is associated with anxiety symptoms in preclinical Alzheimer’s disease
Joyce S Li,
Samantha M Tun,
Bronte Ficek-Tani
et al.
Abstract:BACKGROUNDWhile the amygdala receives early tau deposition in Alzheimer’s disease (AD) and is involved in social and emotional processing, the relationship between amygdalar tau and early neuropsychiatric symptoms in AD is unknown. We sought to determine whether focal tau binding in the amygdala and abnormal amygdalar connectivity were detectable in a preclinical AD cohort and identify relationships between these and self-reported mood symptoms.METHODSWe examined n=598 individuals (n=347 amyloid-positive (58% … Show more
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