Meconium Peritonitis: Correlation of Antenatal Diagnosis and Postnatal Outcome - An Institutional Experience over 10 Years

Ping, Lee May; Rajadurai, Victor Samuel; Saffari, Seyed Ehsan; Chandran, Suresh

doi:10.1159/000449380

Cited by 29 publications

(31 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In another study, Ping et al (n = 18) reported that the presence of a meconium pseudocyst was associated with the need for surgery and poor outcome. However, in their study, the prenatal ultrasound DR of fetal pseudocyst was only16.7%, and the remainder were confirmed histologically only after neonatal surgery . In our cohort, we only had six cases (12.2%) who presented with a pseudocyst on antenatal ultrasound.…”

Section: Discussionmentioning

confidence: 83%

“…However, in their study, the prenatal ultrasound DR of fetal pseudocyst was only16.7%, and the remainder were confirmed histologically only after neonatal surgery. 21 In our cohort, we only had six cases (12.2%) who presented with a pseudocyst on antenatal ultrasound. Interestingly, the incidence of pseudocyst in the surgical group was lower compared with the nonsurgical group, but this did not reach statistical significance.…”

Section: Independent Predictors Of Poor Outcomementioning

confidence: 99%

See 1 more Smart Citation

Predicting poor outcomes and the need for surgical treatment in neonates with meconium peritonitis

et al. 2019

View full text Add to dashboard Cite

Objective The objective of this study is to determine factors associated with poor outcomes and the need for surgical treatment in neonates with meconium peritonitis (MP). Methods We evaluated the association between prenatal ultrasound features, maternal characteristics, and the likelihood of surgery, mortality, and serious morbidity in 49 neonates with a prenatal diagnosis of MP, who were born in Guangzhou Women and Children's Medical Center between January 2011 and December 2016. Results Thirty of 49 neonates (61.2%) required surgical treatment, and 17 (34.7%) had a poor outcome. Independent predictors of need for surgical treatment were polyhydramnios, maternal intrahepatic cholestasis of pregnancy (associated with lower risk), and persistence of peritoneal fluid. The model correctly predicted 70.0% of the neonates who required surgery (at a 10% false‐positive rate; area under the curve [AUC]: 0.86 [95% CI, 0.75‐0.97]). For poor outcomes, independent predictors were low gestational age at birth, persistence of peritoneal fluid, and polyhydramnios. For the latter, the model only achieved a detection rate of 52.9% (10% false‐positive rate, AUC: 0.82 [95% CI, 0.70‐0.94]). Conclusions A combination of prenatal ultrasound features and maternal characteristics correctly predicted 70.0% the need for neonatal surgery. Prediction of poor outcome‐based prenatal ultrasound features and gestational age did not perform well.

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Independent Predictors Of Poor Outcomementioning

confidence: 99%

Predicting poor outcomes and the need for surgical treatment in neonates with meconium peritonitis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…After title and abstract screening, 56 studies were selected for full-text analysis. Fourteen manuscripts met the inclusion criteria and were included for data analysis [2,7,[12][13][14][15][16][19][20][21][22][23][24]. The addition of our institutional findings resulted in a total of 15 studies.…”

Section: Results From Meta-analysismentioning

confidence: 99%

“…In 2 Drittel der Fälle (66,5 %) war eine postnatale abdominale Operation erforderlich. Der stärkste Prädiktor für die neonatale Chirurgie war eine Mekonium-Pseudozyste (OR 6,75; 95 %-KI 2,53-18,01), gefolgt von Darmdilatation (OR 4,17; 95 %-KI 1,93-9,05) und Aszites (OR 2,57; 95 %- KI 1,24). Die häufigste Ursache für Darmperforation und Mekoniumperitonitis, die in 52,2 % der Fälle gefunden wurde, war die Dünndarmatresie.…”

Section: Conclusion Meconium Pseudocysts Bowel Dilation Andunclassified

See 1 more Smart Citation

Fetal Meconium Peritonitis – Prenatal Findings and Postnatal Outcome: A Case Series, Systematic Review, and Meta-Analysis

et al. 2020

View full text Add to dashboard Cite

Purpose To describe the postnatal outcome of fetal meconium peritonitis and identify prenatal predictors of neonatal surgery. Methods We retrospectively reviewed all fetuses with ultrasound findings suspicious for meconium peritonitis at a single center over a 10-year period. A systematic review and meta-analysis were then performed pooling our results with previous studies assessing prenatally diagnosed meconium peritonitis and postnatal outcome. Prenatal sonographic findings were analyzed to identify predictors for postnatal surgery. Results 34 cases suggestive of meconium peritonitis were diagnosed at our center. These were pooled with cases from 14 other studies yielding a total of 244 cases. Postnatal abdominal surgery was required in two thirds of case (66.5 %). The strongest predictor of neonatal surgery was meconium pseudocyst (OR [95 % CI] 6.75 [2.53–18.01]), followed by bowel dilation (OR [95 % CI] 4.17 [1.93–9.05]) and ascites (OR [95 % CI] 2.57 [1.07–5.24]). The most common cause of intestinal perforation and meconium peritonitis, found in 52.2 % of the cases, was small bowel atresia. Cystic fibrosis was diagnosed in 9.8 % of cases. Short-term neonatal outcomes were favorable, with a post-operative mortality rate of 8.1 % and a survival rate of 100 % in neonates not requiring surgery. Conclusion Meconium pseudocysts, bowel dilation, and ascites are prenatal predictors of neonatal surgery in cases of meconium peritonitis. Fetuses with these findings should be delivered in centers with pediatric surgery services. Though the prognosis is favorable, cystic fibrosis complicates postnatal outcomes.

show abstract

Prenatal Diagnosis of Fetal Malformations by Ultrasound

Leeuwen

Lugthart

Pajkrt

2021

Genetic Disorders and the Fetus

View full text Add to dashboard Cite

Meconium Peritonitis: Correlation of Antenatal Diagnosis and Postnatal Outcome - An Institutional Experience over 10 Years

Cited by 29 publications

References 22 publications

Predicting poor outcomes and the need for surgical treatment in neonates with meconium peritonitis

Predicting poor outcomes and the need for surgical treatment in neonates with meconium peritonitis

Fetal Meconium Peritonitis – Prenatal Findings and Postnatal Outcome: A Case Series, Systematic Review, and Meta-Analysis

Prenatal Diagnosis of Fetal Malformations by Ultrasound

Contact Info

Product

Resources

About