Abstract:Certain tissues express both pregnane X receptor (PXR) and constitutive androstane receptor (CAR), and various target genes are cross‐regulated by these receptors. Meclizine was reported to be an inverse agonist and antagonist of human CAR (hCAR) and an activator of human PXR (hPXR) in cell‐based reporter gene assays. Therefore, activation of hPXR by meclizine may attenuate its apparent hCAR inverse agonistic effects. To test this hypothesis, we investigated whether meclizine would still be capable of suppress… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.