Meckel's diverticulum perforation in a newborn positive to Sars-Cov-2

Abstract

The health emergency linked to the Sars-Cov-2 infection represented an absolutely new problem for all health professionals. In particular, the information regarding the spread of the virus in the pediatric field and its manifestations are still incomplete. In this paper we present a case of neonatal infection which, as far as we know, represents one of the few published cases and which occurred in a patient who came to our attention for acute abdomen from intestinal perforation. The perforation was caused by Meckel's diverticulum, an event considered infrequent in the first year of life and almost exceptional in the neonatal period. This case required particular management, putting pediatric surgeons in front of new and difficult to solve problems. New onset clinical events, such as this one described, represent an opportunity for sharing useful data for the creation of universal protocols for the management of patients with problems that are becoming common and of which little is known.

Traumatic jejunal perforation associated with SARS-CoV-2 (COVID-19) infection

“…[7][8][9][10][11] However, most authors suspect that angiotensinconverting enzyme 2 (ACE-2), the primary cellular receptor for SARS-CoV-2, is involved since ACE-2 is highly expressed in the intestinal tract. [1][2][3][4][5][6][7][8]12,13 Consistent with this patient, several reports have documented neutrophilia and increased lymphocytes in COVID-19 patients. [14][15][16][17] Furthermore, autopsies of COVID-19 patients show neutrophil infiltration in pulmonary capillaries and alveolar spaces.…”

“…The possibility that COVID-19 infection causes or contributes to development of gastrointestinal perforations has been raised by several case reports affecting all age groups. [2][3][4][5][6][7][8][9] The most common causes proposed for COVID-19 gastric perforations include high-dose steroids, tocilizumab (an interleukin-6 inhibitor), stress-related mucosal damage, and small vessel thrombosis and nonocclusive mesenteric ischemia. [7][8][9][10][11] However, most authors suspect that angiotensinconverting enzyme 2 (ACE-2), the primary cellular receptor for SARS-CoV-2, is involved since ACE-2 is highly expressed in the intestinal tract.…”

“…1 However, several case reports have suggested a potential role of COVID-19 in causing gastrointestinal perforations. [2][3][4][5][6][7][8][9] We report a case of a gastrointestinal perforation in a COVID-19 patient developing after a motor vehicle accident.…”

Perforated Meckel’s diverticulum in neonates: a report of six cases and systematic review of the literature

“…3 King Faisal Specialist Hospital & Research Center, Jeddah 21499, Saudi Arabia. 4 Children's Hospital, Lahore, Pakistan. 5 Center for Colorectal and Pelvic Reconstruction, Nationwide Children's, Ohio, Columbus, USA.…”

Sigmoid colon perforation in a SARS-CoV-2 positive neonate: a uniqueness report and a brief review

“…Although neonates may show more severe illness manifestations [ 4 ], it is rarely reported that infected neonates with COVID-19 present with intestinal perforation (IP) [ 5 , 6 ].…”