Mechanotransduction in adipocytes

Polycaprolactone nanofibrous mesh reduces foreign body reaction and induces adipose flap expansion in tissue engineering chamber

“…Low extracellular matrix stiffness and stretching (ie, decreased intracellular tension) promote adipogenesis, but compression impedes it. [60][61][62][63][64][65] In our study, less collagen deposition and capsule formation were found in the PCL group at the early and middle stages compared with the control group, which indicated lower extracellular matrix stiffness and intracellular tension in the tissue of the PCL group in this period. This collective finding explains why there were more adipogenic gene (PPARγ) expression at week 4 and larger volume of adipose tissue in the following weeks in the PCL group.…”

Cytoskeleton and plasma-membrane damage resulting from exposure to sustained deformations: A review of the mechanobiology of chronic wounds

“…For example, stretching airway smooth muscle cells modifies the mechanical interactions and changes the tissues function [35] . Similarly, stretching has been shown to accelerate differentiation of adipocytes and production of intracellular lipids [30,42] , and has also caused transient membrane poration [9,10,30,32,33] . Thus, the effects of locally or globally applied mechanical deformations are extensive and far reaching.…”

Mechanical Control of Mesenchymal Stem Cell Adipogenesis

“…Studies have been performed to identify the effects of dietary biochemical factors on obesity using in vitro adipogenesis cell model and in vivo animal studies [1]. Recently, an unconventional non-biochemical approach has been exploited that tests how mechanical stimuli affect cellular commitment and differentiation into adipogenesis [2]. Mechanical factors that could affect the adipogenesis of MSCs or adipose precursor cells include cell stretching, compression, and fluid shear.…”

“…Interestingly, it has been reported that inducing MSC and adipose stem cell fate decision into musculoskeletal lineages by mechanical stimuli may result in the reduction of stem cell commitment into adipogenesis [4,5]. Importantly, cells in adipose tissues are also physiologically exposed to compound mechanical cues (tensile, compressive, and shear) that result from bodyweight loads and weight-bearing, and it is becoming recognized that adipocytic cells and their precursors can be mechanically sensitive and responsive [2]. It is therefore probable that the process of cellular evolution from MSCs and precursor cells into differentiated adipocytes may be influenced by extracellular mechanical signals.…”