2016
DOI: 10.1038/nn.4449
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Mechanosensory hair cells express two molecularly distinct mechanotransduction channels

Abstract: Auditory hair cells contain mechanotransduction channels that rapidly open in response to sound-induced vibrations. Surprisingly, we report here that auditory hair cells contain two molecularly distinct mechanotransduction channels. One ion channel is activated by sound and is responsible for sensory transduction. This sensory transduction channel is expressed in hair-cell stereocilia and previous studies show that its activity is affected by mutations in the genes encoding the transmembrane proteins TMHS/LHFP… Show more

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Cited by 108 publications
(140 citation statements)
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“…GsMTx4 has revealed that MSCS “apparently” contribute significantly to normal short-term and developmental physiology (examples: arterial pressure regulation [110, 111, 119, 120], skeletal muscle pressor reflex [121], cardiac stretch induced slow force response [122], RBC volume regulation [123, 124], neuronal touch and pain sensation [125127], mechanotransduction of sound by OHCs [128, 129], serotonin release by gut epithelium [130], renal epithelium luminal pressure detection [131], etc.). Interestingly, when injected over 6 weeks, the GsMTx4 exposure reached concentrations in most tissues that would inhibit MSCs (nervous system is an exception – GsMTx4 does not appear to cross the blood brain barrier [106, 107]), but with no detectable effect on normal physiology [107].…”
Section: Mscs In Normal Physiology Versus Pathologymentioning
confidence: 99%
“…GsMTx4 has revealed that MSCS “apparently” contribute significantly to normal short-term and developmental physiology (examples: arterial pressure regulation [110, 111, 119, 120], skeletal muscle pressor reflex [121], cardiac stretch induced slow force response [122], RBC volume regulation [123, 124], neuronal touch and pain sensation [125127], mechanotransduction of sound by OHCs [128, 129], serotonin release by gut epithelium [130], renal epithelium luminal pressure detection [131], etc.). Interestingly, when injected over 6 weeks, the GsMTx4 exposure reached concentrations in most tissues that would inhibit MSCs (nervous system is an exception – GsMTx4 does not appear to cross the blood brain barrier [106, 107]), but with no detectable effect on normal physiology [107].…”
Section: Mscs In Normal Physiology Versus Pathologymentioning
confidence: 99%
“…In addition to TMC1/2 and TMIE, Piezo channels, frequently found in proprioceptors and Merkel cells, are also associated with normal function of some hair cells, but are apparently not directly involved in mechanotransduction (Wu et al, 2016). In addition, multiple functionally important links between stereocilia and mechanotransduction defects can be found in various mutations.…”
Section: Introductionmentioning
confidence: 99%
“…It would be important to establish how the stereocilin-mediated connections of stereocilia molecularly relate to the microvilli connections in choanoflagellates and sponges. This could help to reveal the evolutionary origin of the leading candidates for the mechanosensory transduction channel, TMC1/2 (Shibata et al, 2016) and TMHS/TMIE (Wu et al, 2016; Wu and Müller, 2016). …”
Section: Introductionmentioning
confidence: 99%
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“…Hair cells are recognized as primary transducers for perception of sound and balance [2]. In the sensory epithelium, there are also supporting cells that contact the basolateral surfaces of hair cells and mediate hair cell…”
Section: Introductionmentioning
confidence: 99%