“…GsMTx4 has revealed that MSCS “apparently” contribute significantly to normal short-term and developmental physiology (examples: arterial pressure regulation [110, 111, 119, 120], skeletal muscle pressor reflex [121], cardiac stretch induced slow force response [122], RBC volume regulation [123, 124], neuronal touch and pain sensation [125–127], mechanotransduction of sound by OHCs [128, 129], serotonin release by gut epithelium [130], renal epithelium luminal pressure detection [131], etc.). Interestingly, when injected over 6 weeks, the GsMTx4 exposure reached concentrations in most tissues that would inhibit MSCs (nervous system is an exception – GsMTx4 does not appear to cross the blood brain barrier [106, 107]), but with no detectable effect on normal physiology [107].…”