Mechanosensitive membrane domains regulate calcium entry in arterial endothelial cells to protect against inflammation
Soon-Gook Hong,
Julianne W. Ashby,
John P. Kennelly
et al.
Abstract:Endothelial cells (ECs) in the descending aorta are exposed to high laminar shear stress, and this supports an anti-inflammatory phenotype. High laminar shear stress also induces flow-aligned cell elongation and front-rear polarity, but whether these are required for the anti-inflammatory phenotype is unclear. Here, we showed that Caveolin-1-rich microdomains polarize to the downstream end of ECs that are exposed to continuous high laminar flow. These microdomains were characterized by high membrane rigidity, … Show more
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