Abstract:Cells exhibit pathological behaviors in response to increased extracellular matrix (ECM) stiffness, including accelerated cell proliferation and migration, which are correlated with increased intracellular stiffness and tension. The biomechanical signal transduction of ECM stiffness into relevant molecular signals and resultant cellular processes is mediated through multiple proteins associated with the actin cytoskeleton in lamellipodia. However, the molecular mechanisms by which lamellipodial dynamics regula… Show more
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