Mechanosensing in liver regeneration

Song, Ziwei; Gupta, Kapish; Ng, Inn Chuan; Xing, Jiangwa; Yang, Yi; Yu, Hanry

doi:10.1016/j.semcdb.2017.07.041

Cited by 50 publications

(41 citation statements)

References 188 publications

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“…HSCs play a key role in maintaining flow‐mediated sinusoidal tone and stiffness by activation of the RhoA‐ROCK pathway, MLC phosphorylation, and stress fiber contraction. [ 89,366,368 ] Vascular dysfunction arising out of portal hypertension, inflammation or alcoholic damage causes defenestration (or capillarization) of LSECs, deposition of laminin and fibronectin, activation of HSCs toward a proliferative, procontractile phenotype, reduced NO production, increased ROS generation, and abnormal sensitivity to vasomodulation, thereby hindering oxygenation of hepatocytes. [ 366,367,369 ] This eventually leads to necroptosis of hepatocytes and chronic liver disease (cirrhosis).…”

Section: Modeling Vascular Mechanopathology In Vascularized Microphysmentioning

confidence: 99%

“…[ 366,367 ] Abnormal flow patterns are also associated with platelet recruitment and aggregation, imbalance in pro‐ and anti‐coagulant factors, coagulation and clot formation, and recruitment and adhesion of leukocytes, thereby leading to vessel occlusion and an increase in intrahepatic vascular resistance and pressure. [ 366,368 ] Interestingly, recovery from acute liver injury or hepatectomy is also dependent on increases in shear stress and flow, which induces release of NO from LSECs and HSCs and sensitizes hepatocytes to hepatocyte growth factor (HGF) necessary for proliferation and regeneration. [ 368,370 ]…”

Section: Modeling Vascular Mechanopathology In Vascularized Microphysmentioning

confidence: 99%

“…[ 366,368 ] Interestingly, recovery from acute liver injury or hepatectomy is also dependent on increases in shear stress and flow, which induces release of NO from LSECs and HSCs and sensitizes hepatocytes to hepatocyte growth factor (HGF) necessary for proliferation and regeneration. [ 368,370 ]…”

Section: Modeling Vascular Mechanopathology In Vascularized Microphysmentioning

confidence: 99%

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Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology

Pradhan

Banda

Farino

et al. 2020

Adv Healthcare Materials

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The vascular system is integral for maintaining organ‐specific functions and homeostasis. Dysregulation in vascular architecture and function can lead to various chronic or acute disorders. Investigation of the role of the vascular system in health and disease has been accelerated through the development of tissue‐engineered constructs and microphysiological on‐chip platforms. These in vitro systems permit studies of biochemical regulation of vascular networks and parenchymal tissue and provide mechanistic insights into the biophysical and hemodynamic forces acting in organ‐specific niches. Detailed understanding of these forces and the mechanotransductory pathways involved is necessary to develop preventative and therapeutic strategies targeting the vascular system. This review describes vascular structure and function, the role of hemodynamic forces in maintaining vascular homeostasis, and measurement approaches for cell and tissue level mechanical properties influencing vascular phenomena. State‐of‐the‐art techniques for fabricating in vitro microvascular systems, with varying degrees of biological and engineering complexity, are summarized. Finally, the role of vascular mechanobiology in organ‐specific niches and pathophysiological states, and efforts to recapitulate these events using in vitro microphysiological systems, are explored. It is hoped that this review will help readers appreciate the important, but understudied, role of vascular‐parenchymal mechanotransduction in health and disease toward developing mechanotherapeutics for treatment strategies.

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Section: Modeling Vascular Mechanopathology In Vascularized Microphysmentioning

confidence: 99%

Section: Modeling Vascular Mechanopathology In Vascularized Microphysmentioning

confidence: 99%

Section: Modeling Vascular Mechanopathology In Vascularized Microphysmentioning

confidence: 99%

See 1 more Smart Citation

Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology

Pradhan

Banda

Farino

et al. 2020

Adv Healthcare Materials

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“…Though faced with many challenges including scaling up of the processes, regenerative medicine technologies are expanding and are likely to impact on patients' treatment in future. Several natural ECMs have been approved by the Food and Drug Administration (FDA) for use as therapies for diverse conditions as wound healing and liver regeneration [191][192][193][194][195]. Cells such as fibroblasts and keratinocytes have been utilized together with collagen for the treatment of venous and foot ulcers [196,197].…”

Section: Manufacturing and Regulatory Process Considerationsmentioning

confidence: 99%

Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: Inspiring a new Kind of Medicine

Dzobo¹,

Motaung²,

Adesida³

2019

Preprint

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The promise of regenerative medicine and tissue engineering is founded on the ability to regenerate diseased or damaged tissues and organs into functional tissues and organs or the creation of new tissues and organs altogether. In theory, all damaged and diseased tissues and organs can be regenerated or created using different configurations and combinations of extracellular matrix, cells and inductive biomolecules. Currently, regenerative medicine and tissue engineering can allow the improvement of patients’ quality of life through availing novel treatment options. Tissues and organs have a specific ECM, with specific proteins and factors released by cells residing within the local microenvironment. The coupling of regenerative medicine and tissue engineering field with 3D printing is revolutionizing the treatment of patients in a huge way. 3D bioprinting allows the proper placement of cells and ECMs, allowing the recapitulation of native microenvironments of tissues and organs. 3D bioprinting utilizes different bioinks made up of different formulations of ECM/biomaterials, biomolecules and even cells. The choice of the bioink used during 3D bioprinting is very important as properties such as printability, compatibility and physical strength influence the final construct printed. The extracellular matrix (ECM) provides both physical and mechanical microenvironment needed by cells to survive and proliferate. Decellularized ECM bioink contains biochemical cues from the original native ECM and also the right proportions of ECM proteins. Different techniques and characterization methods are used to derive bioinks from several tissues and organs and to evaluate their quality. This review discusses the uses of decellularized ECM bioinks and argues that they represent the most biomimetic bioinks available. In addition, we briefly discuss some polymer-based bioinks utilized in 3D bioprinting.

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“…Liver tissue has unique regenerative ability to recover its function and original volume even after 70% of partial hepatectomy [88]. On a microstructural level, the functional unit of liver is hepatic lobule, which carries on the crucial functions of secretion and detoxification [5].…”

Section: Bioprinting Of Livermentioning

confidence: 99%

3D bioprinting for cell culture and tissue fabrication

Jian

Wang

et al. 2018

Bio-des. Manuf.

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Three-dimensional (3D) bioprinting is a computer-assisted technology which precisely controls spatial position of biomaterials, growth factors and living cells, offering unprecedented possibility to bridge the gap between structurally mimic tissue constructs and functional tissues or organoids. We briefly focus on diverse bioinks used in the recent progresses of biofabrication and 3D bioprinting of various tissue architectures including blood vessel, bone, cartilage, skin, heart, liver and nerve systems. This paper provides readers a guideline with the conjunction between bioinks and the targeted tissue or organ types in structuration and final functionalization of these tissue analogues. The challenges and perspectives in 3D bioprinting field are also illustrated.

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Mechanosensing in liver regeneration

Cited by 50 publications

References 188 publications

Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology

Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology

Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: Inspiring a new Kind of Medicine

3D bioprinting for cell culture and tissue fabrication

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