Mechanosensing by Piezo1 and its implications in the kidney
Xi Yuan,
Xiaoduo Zhao,
Weidong Wang
et al.
Abstract:Piezo1 is an essential mechanosensitive transduction ion channel in mammals. Its unique structure makes it capable of converting mechanical cues into electrical and biological signals, modulating biological and (patho)physiological processes in a wide variety of cells. There is increasing evidence demonstrating that the piezo1 channel plays a vital role in renal physiology and disease conditions. This review summarizes the current evidence on the structure and properties of Piezo1, gating modulation, and pharm… Show more
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