Mechanoresponsive Properties of the Periodontal Ligament

Huang, Li; Liu, B.; Yul, Jung; Gao, Yuan; Kelly, Meghan; Singh, Gurdev; Hyman, Sydnee; Brunski, John B.; Li, J.; Helms, Jill A.

doi:10.1177/0022034515626102

Cited by 33 publications

(32 citation statements)

References 38 publications

(35 reference statements)

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“…Mitotic activity, however, was on the rise. In intact dentition, the PDL is a quiescent tissue (Huang, Liu, et al 2016). Proliferating cell nuclear antigen (PCNA) immunostaining of the mnM1 PDL confirmed the scarcity of proliferating cells in the PDLs of mice with intact dentition (Fig.…”

Section: Hyperloading Instigates a Series Of Catabolic And Anabolic Rmentioning

confidence: 69%

Mechanoadaptive Responses in the Periodontium Are Coordinated by Wnt

Yuan

Zhang

et al. 2019

J Dent Res

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Despite an extensive literature documenting the adaptive changes of bones and ligaments to mechanical forces, our understanding of how tissues actually mount a coordinated response to physical loading is astonishingly inadequate. Here, using finite element (FE) modeling and an in vivo murine model, we demonstrate the stress distributions within the periodontal ligament (PDL) caused by occlusal hyperloading. In direct response, a spatially restricted pattern of apoptosis is triggered in the stressed PDL, the temporal peak of which is coordinated with a spatially restricted burst in PDL cell proliferation. This culminates in increased collagen deposition and a thicker, stiffer PDL that is adapted to its new hyperloading status. Meanwhile, in the adjacent alveolar bone, hyperloading activates bone resorption, the peak of which is followed by a bone formation phase, leading ultimately to an accelerated rate of mineral apposition and an increase in alveolar bone density. All of these adaptive responses are orchestrated by a population of Wnt-responsive stem/progenitor cells residing in the PDL and bone, whose death and revival are ultimately responsible for directly giving rise to new PDL fibers and new bone.

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Section: Hyperloading Instigates a Series Of Catabolic And Anabolic Rmentioning

confidence: 69%

Mechanoadaptive Responses in the Periodontium Are Coordinated by Wnt

Yuan

Zhang

et al. 2019

J Dent Res

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“…Importantly, the newly formed PDL‐like fibers grew into the surrounding alveolar bone, contributing to the integration of PDL‐like fibers with alveolar bone remodeling. This structure would enhance the maintenance of the xenogeneic bio‐root in the jaws and provide the necessary supply for mechanical loading . Moreover, the newly formed blood vessels and nervous tissues (positively stained for βIII‐tubulin) indicated good perfusion of nutrients into the PDL‐like fibers .…”

Section: Discussionmentioning

confidence: 99%

Xenogeneic Bio‐Root Prompts the Constructive Process Characterized by Macrophage Phenotype Polarization in Rodents and Nonhuman Primates

Sun

et al. 2017

Adv Healthcare Materials

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Tissue or organ regeneration using xenogeneic matrices is a promising approach to address the shortage of donor matrices for allotransplantation. Success of such approach has been demonstrated to correlate with macrophage-mediated fibrotic homeostasis and tissue remodeling. The previous studies have demonstrated that treated dentin matrix (TDM) could be a suitable bioactive substrate for allogeneic tooth root regeneration. This study constructed xenogeneic bioengineered tooth root (bio-root) via a combination of porcine TDM (pTDM) with allogeneic dental follicle cells (DFCs). Macrophage phenotypes are used to evaluate the remodeling process of xenogeneic bio-roots in vitro and in vivo. pTDM can facilitate odontoblast differentiation of human derived DFCs. Xenogeneic bio-roots in rat subcutaneous tissue prompt constructive response via M1 macrophage infiltration during early postimplantation stages and increase restorative M2 phenotype at later stages. After implantation of bio-roots into jaws of rhesus monkeys for six months, periodontal ligament-like fibers accompanied by macrophage polarization are observed, which are positive for COL-1, Periostin, βIII-tubulin and display such structures as fibroblasts and blood vessels. The reconstructed bio-root possesses biomechanical properties for the dissipation of masticatory forces. These results support that xenogeneic bio-root could maintain fibrotic homeostasis during remodeling process and highlight the potential application of xenogeneic matrices in regenerative medicine.

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“…Zu solchen Zell-Verhaltensantworten zählen grundsätzliche Entscheidungen der Zelle, wie z. B. die Zellteilung oder auch Proliferation [2], die Zellreifung oder auch Differenzierung und der programmierte Zelltod oder auch Apoptose sowie die Migration, die die Wanderung von Zellen beschreibt.…”

Section: Die Biologie Der Orthodontischen Zahnbewegung -Status Quo Deunclassified