Mechanoreceptors and Free Nerve Endings

Malinovský, L

doi:10.1007/978-3-662-00989-5_27

Cited by 30 publications

(39 citation statements)

References 30 publications

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“…The main structural (Halata, 1975;Iggo and Andres, 1982;Malinovsky, 1986;Munger and Ide, 1988;Zelena, 1994), biochemical (see Dubový, 1996), and immunohistochemical (see Vega et al, 1996b) characteristics of the cells forming sensory corpuscles have been extensively analyzed. Studies on corpuscular changes following injuries of the nerves supplying them are also abundant and have been so far addressed mainly to structural (for references see Zelena, 1994) and histochemical (see Dubový and Aldskogius, 1996) aspects.…”

Section: Discussionmentioning

confidence: 99%

p75 and TrkA neurotrophin receptors in human skin after spinal cord and peripheral nerve injury, with special reference to sensory corpuscles

et al. 1998

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Human skin, including nerves and sensory corpuscles, displays immunoreactivity (IR) for low-(p75) and high-affinity (TrkA-like) receptors for nerve growth factor (NGF), the best characterized member of the family of neurotrophins. This study was designed to analyze the changes induced by spinal cord and peripheral nerve injuries in the expression of neurotrophin receptors in digital skin, with special reference to nerves and sensory corpuscles.Skin biopsy samples were obtained from 1) the hand and toes of normal subjects, 2) below the level of the lesion of patients with spinal cord injury affecting dorsal and lateral funiculi, 3) the cutaneous territory of entrapped peripheral nerves (median and ulnar nerves), and 4) the cutaneous territory of sectioned and grafted nerves (median nerve). The pieces were formalinfixed and paraffin-embedded, cut in serial sections, and processed for immunohistochemistry using antibodies against human p75 and TrkA proteins. The percentage of sensory corpuscles displaying IR for p75 and TrkA-like, as well as the intensity of IR developed within them, was assessed using quantitative image analysis.Spinal cord severance causes a decrease in p75 IR in Meissner and Pacinian corpuscles, whereas TrkA-like IR did not vary. In other nonnervous tissues (i.e., epidermis, sweat glands), both p75 and TrkA-like IR was diminished or even absent. Similar but more severe changes were encountered in the skin from the territory of entrapped nerves. Finally, in subjects with sectioned-grafted nerves, p75 IR was found close to controls in nerves, reduced in Meissner corpuscles, and absent in the inner core of the Pacinian ones; TrkA-like IR was in the perineurium, a small percentage of Meissner corpuscles (about 7%), and the outer core and capsule of the Pacinan corpuscles. In the nonnervous tissues, p75 IR was practically absent, whereas TrkA-like IR did not change. No changes in the expression of neurotrophin receptors were observed in Merkel cells of the different groups.Present results show the following: 1) expression of nerve p75 IR in human cutaneous sensory corpuscles is sensitive to central deafferentation, to blockade or difficulty in axonal transport, and to disruption of axonal

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Section: Discussionmentioning

confidence: 99%

p75 and TrkA neurotrophin receptors in human skin after spinal cord and peripheral nerve injury, with special reference to sensory corpuscles

et al. 1998

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“…Since type I endings likely represent afferent mechanoceptors with a low threshold which is slowly adapting [Freeman and Wyke. 1967;Malinovsky. 1986], it is possible that this type of afferent mechanisms is predominantly elaborated in the articular capsule and the cruciate ligaments.…”

Section: Discussionmentioning

confidence: 99%

“…The main information concerning the innervation of joints was obtained primarily using classical neurohistological techniques involving gold, silver or silver-gold impregnation methods [for a review, see Malinovsky, 1986]. These techniques, although able to provide rather impressive images concerning the anatomical organiza tion of nerve fibres, endings and corpuscle receptors, present the disadvantage of being rather difficult to repro duce and leave a great deal to be desired in terms of selec tivity for nervous tissue [Baljet and Drukker.…”

Section: Discussionmentioning

confidence: 99%

Intrinsic Innervation of the Rat Knee Joint Articular Capsule and Ligaments

Marinozzi¹,

Ferrante

Gaudio³

et al. 1991

Cells Tissues Organs

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In spite of the practical importance of having a detailed knowledge of knee joint innervation to understand the pathophysiologic aspects, little information is now available concerning the density and pattern of the nerve fibres which are distributed to it. The present study has been designed to investigate the density and distribution of nerve fibres and receptor corpuscles in the knee joint articular capsule, cruciate and collateral ligaments in the rat, using the acetylcholinesterase (AChE) histochemical in toto staining technique. The investigation was performed on male Wistar rats of 3 months of age some of which had been treated with capsaicin to deplete their afferent ‘C fibres of their content of neuropeptides. AChE-positive nerve fibres and different types of receptor corpuscle endings were found within articular capsule and ligaments. The highest density of AChE-positive nerve fibres was noticeable in the fibular collateral ligament followed by the tibial collateral ligament, the posterior cruciate ligament, the anterior cruciate ligament and the articular capsule. In the articular capsule the number of type I endings was higher than in the ligaments. The opposite is true for the other type of receptor corpuscles found as well as for nerve endings. Capsaicin treatment significantly reduced the density of AChE-positive nerve fibres in knee joint ligaments but did not affect nerve fibres in the articular capsule. Moreover, it caused the disappearance of some kind of receptor corpuscles within the collateral and cruciate ligaments. The above data collectively suggest that the AChE in toto staining technique may represent a good method for investigating joint innervation and that a significant percentage of nerve fibres supplying knee joint ligaments is represented by C fibre afferents.

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“…In our classification (Malinovsky, 1986(Malinovsky, ,1989a,b) we tried to join morphological features with physiological velocity of adaptation. The dendritic zone in simple SNF, arborizations, Ruffini SNF, Golgi tendon SNF and neuromuscular spindles is surrounded by an accumulation of connective or muscular tissue elements which are of mesodermal origin.…”

Section: Basis Of the New Classification Ofmentioning

confidence: 99%