Mechanomyographic response to transcranial magnetic stimulation from biceps brachii and during transcutaneous electrical nerve stimulation on extensor carpi radialis

Reza, Mohammed Faruque; Ikoma, Katsunori; Chuma, Takayo; Mano, Yukio

doi:10.1016/j.jneumeth.2005.05.013

Cited by 13 publications

(15 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TMS-MMG methods have been described in humans shown to be highly correlated to the MEP (Reza et al 2005). In the present study, we find analogous results in rats.…”

Section: Discussionsupporting

confidence: 88%

“…However the requirement for anesthesia in rat ppTMS presents a number of problems: 1) it distinguishes rat from human ppTMS protocols where no anesthesia is required; 2) it is a confounding factor for interpreting the pharmacology of cortical inhibition; and 3) depending on the anesthetic choice and choice of animal model, general anesthesia may be either injurious or neuroprotective and thus may alter cortical physiology, particularly rodent models of brain injury. Accordingly, we developed novel methods for ppTMS in unanesthetized rats that rely on the mechanomyogram (MMG; Reza et al 2005), a technique where motor cortex activation is detected and quantified by limb accelerometry rather than needle EMG where anesthesia is required.…”

mentioning

confidence: 99%

See 1 more Smart Citation

A new measure of cortical inhibition by mechanomyography and paired-pulse transcranial magnetic stimulation in unanesthetized rats

Hsieh

Dhamne

Chen

et al. 2012

Journal of Neurophysiology

View full text Add to dashboard Cite

A new measure of cortical inhibition by mechanomyography and paired-pulse transcranial magnetic stimulation in unanesthetized rats. J Neurophysiol 107: 966 -972, 2012. First published October 19, 2011 doi:10.1152/jn.00690.2011.-Paired-pulse transcranial magnetic stimulation (ppTMS) is a safe and noninvasive tool for measuring cortical inhibition in humans, particularly in patients with disorders of cortical inhibition such as epilepsy. However, ppTMS protocols in rodent disease models, where mechanistic insight into the ppTMS physiology and into disease processes may be obtained, have been limited due to the requirement for anesthesia and needle electromyography. To eliminate the confounding factor of anesthesia and to approximate human ppTMS protocols in awake rats, we adapted the mechanomyogram (MMG) method to investigate the ppTMS inhibitory phenomenon in awake rats and then applied differential pharmacology to test the hypothesis that long-interval cortical inhibition is mediated by the GABA A receptor. Bilateral hindlimbevoked MMGs were elicited in awake rats by long-interval ppTMS protocols with 50-, 100-, and 200-ms interstimulus intervals. Acute changes in ppTMS-MMG were measured before and after intraperitoneal injections of saline, the GABA A agonist pentobarbital (PB), and GABA A antagonist pentylenetetrazole (PTZ). An evoked MMG was obtained in 100% of animals by single-pulse stimulation, and ppTMS resulted in predictable inhibition of the test-evoked MMG. With increasing TMS intensity, MMG amplitudes increased in proportion to machine output to produce reliable input-output curves. Simultaneous recordings of electromyography and MMG showed a predictable latency discrepancy between the motor-evoked potential and the evoked MMG (7.55 Ϯ 0.08 and 9.16 Ϯ 0.14 ms, respectively). With pharmacological testing, time course observations showed that ppTMS-MMG inhibition was acutely reduced following PTZ (P Ͻ 0.05), acutely enhanced after PB (P Ͻ 0.01) injection, and then recovered to pretreatment baseline after 1 h. Our data support the application of the ppTMS-MMG technique for measuring the cortical excitability in awake rats and provide the evidence that GABA A receptor contributes to long-interval paired-pulse cortical inhibition. Thus ppTMS-MMG appears a well-tolerated biomarker for measuring GABA A -mediated cortical inhibition in rats.long-interval intracortical inhibition; mechanomyogram; GABA TRANSCRANIAL MAGNETIC STIMULATION (TMS) is a well-tolerated technique for measuring regional cortical excitability that is gaining acceptance as a means to examine cortical physiology in healthy human subjects and in patients with neurological disorders such as epilepsy, stroke, and mild concussion (Manganotti et al. 2001(Manganotti et al. , 2008Tremblay et al. 2011;Valzania et al. 1999). In TMS, the cortex is activated by a powerful fluctuating extracranial magnetic field, which induces small intracranial electrical currents (reviewed in Kobayashi and PascualLeone 2003). In humans, TMS can be applied to the moto...

show abstract

“…TMS-MMG methods have been described in humans shown to be highly correlated to the MEP (Reza et al 2005). In the present study, we find analogous results in rats.…”

Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 99%

A new measure of cortical inhibition by mechanomyography and paired-pulse transcranial magnetic stimulation in unanesthetized rats

Hsieh

Dhamne

Chen

et al. 2012

Journal of Neurophysiology

View full text Add to dashboard Cite

show abstract

“…II) MMG signal processing (8). III) MMG applications (63), subdivided into: (i) characterizations of muscle activity (45), further fragmented into: a). fatigue and strength assessment (16), b) muscle force and torque evaluation (9), c) muscle balance and movement studies (3), d) contractile properties and muscle activity (8), e) studying MU activities (4), muscle fiber composition (3) and f) muscle wave propagation properties (2) and (ii) MMG in exercise and medical applications (18), subdivided into: a) MMG measurement in exercises (5), b) neuromuscular disorder assessment (6), c) medical rehabilitation (2) and d) prosthesis and/or switch control (5).…”

Section: Resultsmentioning

confidence: 99%

“…These applications include, for example, the characterization of neuromuscular disorders [40]- [42], the development of prosthesis and/or switch control [28], [43], studying MU activity [21], [44], [45], examining mechanical properties during exercises [46]- [48], and in investigating rehabilitation systems [49], [50]. In addition, we have found several studies which conducted research on MMG sensor development [7], [26], [51], simultaneously testing multiple sensors and comparing their effects on muscles [52], [53].…”

mentioning

confidence: 99%

Mechanomyography Sensor Development, Related Signal Processing, and Applications: A Systematic Review

et al. 2013

View full text Add to dashboard Cite

Mechanomyography (MMG) is extensively used in the research of sensor development, signal processing, characterization of muscle activity, development of prosthesis and/or switch control, diagnosis of neuromuscular disorders, and as a medical rehabilitation tool. Despite much existing MMG research, there has been no systematic review of these. This paper aims to determine the current status of MMG in sensor development, related signal processing, and applications. Six electronic databases were extensively searched for potentially eligible studies published between 2003 and 2012. From a total of 175 citations, 119 were selected for full-text evaluation and 86 potential studies were identified for further analysis. This systematic review initially reveals that the development of accelerometers for MMG is still in the initial stage. Another important finding of this paper is that sensor placement location on muscles may influence the MMG signal. In addition, we observe that the majority of research processes MMG signals using wavelet transform. Time/frequency domain analysis of MMG signals provides useful information to examine muscle. In addition, we find that MMG may be applied to diagnose muscle conditions, to control prosthesis and/or switch devices, to assess muscle activities during exercises, to study motor unit activity, and to identify the type of muscle fiber. Finally, we find that the majority of the studies use accelerometers as sensors for MMG measurements. We also observe that currently MMG-based rehabilitation is still in a nascent stage. In conclusion, we recommend further improvements of MMG in the areas of sensor development, particularly on accelerometers, and signal processing aspects, as well as increasing future applications of the technique in prosthesis and/or switch control, clinical practices, and rehabilitation.

show abstract

“…Surface MMG has been classically recorded with a single sensor placed generally over the muscle belly to assess muscle fatigue (Madeleine et al, 2002;Orizio et al, 2003), muscle pain (Madeleine and Arendt-Nielsen, 2005), neuromuscular diseases (Barry et al, 1990) and responses to transcranial magnetic stimulation (Reza et al, 2005). Recently, one-dimensional arrays composed of eight accelerometers were used to assess the MMG over a larger part of the muscle (Cescon et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Spatial and force dependency of mechanomyographic signal features

Madeleine

Cescon

Farina

2006

Journal of Neuroscience Methods

View full text Add to dashboard Cite

Mechanomyographic response to transcranial magnetic stimulation from biceps brachii and during transcutaneous electrical nerve stimulation on extensor carpi radialis

Cited by 13 publications

References 34 publications

A new measure of cortical inhibition by mechanomyography and paired-pulse transcranial magnetic stimulation in unanesthetized rats

A new measure of cortical inhibition by mechanomyography and paired-pulse transcranial magnetic stimulation in unanesthetized rats

Mechanomyography Sensor Development, Related Signal Processing, and Applications: A Systematic Review

Spatial and force dependency of mechanomyographic signal features

Contact Info

Product

Resources

About