Mechanochromic Detection for Soft Opto-Magnetic Actuators

Güell‐Grau, Pau; Escudero, Pedro; Perdikos, Filippos Giannis; López-Barberá, José Francisco; Pascual-Izarra, C.; Villa, Rosa; Nogués, J.; Sepúlveda, Borja; Álvarez, Mar

doi:10.1021/acsami.1c11710

Cited by 14 publications

(19 citation statements)

References 52 publications

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“…The undefined broad absorption band is a result of the highly damped plasmonic behavior of the metallic iron, whose imaginary part of the dielectric constant is much higher than that in the typical plasmonic metals, such as Ag and Au. 24,25 Interestingly, the absorbance variations can be used to analyze the degradation of the iron semishell during time. As can be observed in Figure 2D, the absorbance spectrum of the nanocapsules shows a fast decrease in the whole visible range during the first 4 days (ca.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the optical properties (Figure D), the MAPSULES present an intense broadband absorbance that slightly decreases toward shorter wavelengths due to the scattering reduction in this region. The undefined broad absorption band is a result of the highly damped plasmonic behavior of the metallic iron, whose imaginary part of the dielectric constant is much higher than that in the typical plasmonic metals, such as Ag and Au. , …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsunclassified

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Efficient Tumor Eradication at Ultralow Drug Concentration via Externally Controlled and Boosted Metallic Iron Magnetoplasmonic Nanocapsules

Fluksman

Lafuente

et al. 2022

ACS Nano

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With the aim to locally enhance the efficacy of cancer nanotherapies, here we present metal iron based magnetoplasmonic drug-loaded nanocapsules (MAPSULES), merging powerful external magnetic concentration in the tumor and efficient photothermal actuation to locally boost the drug therapeutic action at ultralow drug concentrations. The MAPSULES are composed of paclitaxel-loaded polylactic-co-glycolic acid (PLGA) nanoparticles partially coated by a nanodome shape iron/silica semishell. The iron semishell has been designed to present a ferromagnetic vortex for incorporating a large quantity of ferromagnetic material while maintaining high colloidal stability. The large iron semishell provides very strong magnetic manipulation via magnetophoretic forces, enabling over 10-fold higher trapping efficiency in microfluidic channels than typical superparamagnetic iron oxide nanoparticles. Moreover, the iron semishell exhibits highly damped plasmonic behavior, yielding intense broadband absorbance in the near-infrared biological windows and photothermal efficiency similar to the best plasmonic nanoheaters. The in vivo therapeutic assays in a mouse xenograft tumor model show a high amplification of the therapeutic effects by combining magnetic concentration and photothermal actuation in the tumor, leading to a complete eradication of the tumors at ultralow nanoparticle and drug concentration (equivalent to only 1 mg/kg PLGA nanoparticles containing 8 μg/kg of paclitaxel, i.e., 100−500-fold lower than the therapeutic window of the free and PLGA encapsulated drug and 13−3000-fold lower than current nanotherapies combining paclitaxel and light actuation). These results highlight the strength of this externally controlled and amplified therapeutic approach, which could be applied to locally boost a wide variety of drugs for different diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Efficient Tumor Eradication at Ultralow Drug Concentration via Externally Controlled and Boosted Metallic Iron Magnetoplasmonic Nanocapsules

Fluksman

Lafuente

et al. 2022

ACS Nano

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“…[76] By embedding a 1D PhC formed by periodically arranged dielectric NRs in a deformable PDMS substrate, different planar strains could be identified, including their application direction, type, and value. [77] 2D PhCs composed of periodic cylinder-shaped air holes in a triangular lattice, made in PDMS by NIL could distinguish [63] Copyright 2021, American Chemical Society. b) SEM image of different micropatterned shape-memory polymers for programmable micro-optics.…”

Section: Mechanochromic Systems Based On Other Nanoplasmonic Interact...mentioning

confidence: 99%

Soft Optomechanical Systems for Sensing, Modulation, and Actuation

Pujol‐Vila

Güell‐Grau

Nogués

et al. 2023

Adv Funct Materials

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respond to one or more external stimuli (e.g., light, temperature, strain, humidity, pH or electromagnetic fields) by changing their own properties (e.g., shape, size, viscosity, stiffness, color, among others). In this framework, soft optomechanical materials have the capacity to merge the unique optical properties of plasmonic and/or photonic structures, carbon-based nanomaterials (CNMs) or macromolecules with the high tunability and elasticity of soft polymers. Given the high transparency of many soft polymers in the visible and near-infrared (NIR) spectral ranges, together with the possibility to incorporate such optical structures with high compliancy in polymers that can withstand large mechanical deformations, makes this combination of optical and mechanical features ideal for the development of functional optomechanical devices. [1] Soft optomechanical systems can be designed to change their optical properties under mechanical stimuli induced, for example, by strain, temperature, pH and so on, to develop cost-effective and highly sensitive sensors and optical modulators handling large strains, keeping their properties after many deformation cycles and adapting to complex and irregular surfaces. Note that, for example, sensors detecting mechanical deformations (e.g., strain or displacements) are required in structures such as buildings, vehicles, packages or wearable devices, where it is necessary to determine the experienced mechanical stress. Conversely, mechanical sensors can be used as transducers to detect other kind of external stimuli (e.g., chemical, biochemical, optical, to mention a few) that are able to produce mechanical deformations in the material. This category includes, e.g., some biosensors and micro-electromechanical systems (MEMS) that have been widely developed during the last decade. Soft mechanical sensors require a compliant transducer, being the electrical and optical transduction methods the most widely developed. However, optical transduction offers several advantages, particularly, its wireless detection nature, high sensitivity, easy readout, and the capacity to provide 2D strain mapping, even with sub-micron scale spatial resolution. [2][3][4] The high optical tunability of soft optomechanical systems by external mechanical stimuli can also be exploited to build mechanical modulators to modify the color or transparency of surfaces, having great potential in the development of smart windows, [5] rewritable optical displays, encryption, and anticounterfeiting applications, [6] among others. [7]

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“…Consequently, stimulus-responsive mechanochromic color change is obtainable via the chemical, [46][47][48][49] light, [50] magnetic, [51,52] electrical, [24,53] and thermal control [54][55][56] of an organogel lattice. Therefore, configuring the elastic mechanochromic lattice of an organogel can overcome the major technical challenges obstructing an easy reproduction process and can dynamically control the emission wavelength of artificial photonic crystals.…”

Section: Introductionmentioning

confidence: 99%

Color‐Tuning Mechanism of Electrically Stretchable Photonic Organogels

et al. 2022

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In contrast to nano‐processed rigid photonic crystals with fixed structures, soft photonic organic hydrogel beads with dielectric nanostructures possess advanced capabilities, such as stimuli‐responsive deformation and photonic wavelength color changes. Recenlty, advanced from well‐investigated mechanochromic method, an electromechanical stress approach is used to demonstrate electrically induced mechanical color shifts in soft organic photonic hydrogel beads. To better understand the electrically stretchable color change functionality in such soft organic photonic hydrogel systems, the electromechanical wavelength‐tuning mechanism is comprehensively investigated in this study. By employing controllable electroactive dielectric elastomeric actuators, the discoloration wavelength‐tuning process of an electrically stretchable photonic organogel is carefully examined. Based on the experimental in‐situ response of electrically stretchable nano‐spherical polystyrene hydrogel beads, the color change mechanism is meticulously analyzed. Further, changes in the nanostructure of the symmetrically and electrically stretchable organogel are analytically investigated through simulations of its hexagonal close‐packed (HCP) lattice model. Detailed photonic wavelength control factors, such as the refractive index of dielectric materials, lattice diffraction, and bead distance in an organogel lattice, are theoretically studied. Herein, the switcing mechanism of electrically stretchable mechanochromic photonic organogels with photonic stopband‐tuning features are suggested for the first time.

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Mechanochromic Detection for Soft Opto-Magnetic Actuators

Cited by 14 publications

References 52 publications

Efficient Tumor Eradication at Ultralow Drug Concentration via Externally Controlled and Boosted Metallic Iron Magnetoplasmonic Nanocapsules

Efficient Tumor Eradication at Ultralow Drug Concentration via Externally Controlled and Boosted Metallic Iron Magnetoplasmonic Nanocapsules

Soft Optomechanical Systems for Sensing, Modulation, and Actuation

Color‐Tuning Mechanism of Electrically Stretchable Photonic Organogels

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