Mechanochemical tools for polymer materials

Chen, Yinjun; Mellot, Gaëlle; Luijk, Diederik van; Creton, Costantino; Sijbesma, RP Rint

doi:10.1039/d0cs00940g

Cited by 259 publications

(244 citation statements)

References 223 publications

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“…In polymer mechanochemistry, force‐reactive functional molecular motifs (mechanophores) are designed such that they undergo transformations on the molecular level by rearranging or cleaving bonds with reasonable specificity [29–34] . Mechanophore activation can occur not only in bulk material by exposure to mechanical stress and strain but also in solution via the collapse of US‐induced cavitation bubbles generating shear stress [35] .…”

Section: Introductionmentioning

confidence: 99%

Activation of the Catalytic Activity of Thrombin for Fibrin Formation by Ultrasound

et al. 2021

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The regulation of enzyme activity is a method to control biological function. We report two systems enabling the ultrasound‐induced activation of thrombin, which is vital for secondary hemostasis. First, we designed polyaptamers, which can specifically bind to thrombin, inhibiting its catalytic activity. With ultrasound generating inertial cavitation and therapeutic medical focused ultrasound, the interactions between polyaptamer and enzyme are cleaved, restoring the activity to catalyze the conversion of fibrinogen into fibrin. Second, we used split aptamers conjugated to the surface of gold nanoparticles (AuNPs). In the presence of thrombin, these assemble into an aptamer tertiary structure, induce AuNP aggregation, and deactivate the enzyme. By ultrasonication, the AuNP aggregates reversibly disassemble releasing and activating the enzyme. We envision that this approach will be a blueprint to control the function of other proteins by mechanical stimuli in the sonogenetics field.

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Section: Introductionmentioning

confidence: 99%

Activation of the Catalytic Activity of Thrombin for Fibrin Formation by Ultrasound

et al. 2021

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“…Thef ield of polymer mechanochemistry aims to use mechanical forces to trigger chemical transformations within polymers,o ften with the aid of mechanophores (forceresponsive moieties). [1][2][3][4][5][6][7][8][9] Mechanoresponsive polymers have been targeted for diverse solution-and solid-state applications,i ncluding catalysis, [10,11] drug-delivery, [12,13] force sensors, [14,15] and self-healing/strengthening materials. [16,17] Va rious design principles influence mechanochemical reactivity including the location of mechanophores, [18] regio-and stereochemistry, [19][20][21][22][23] linkers, [24][25][26] polymer composition, [27,28] and polymer topology.…”

Section: Introductionmentioning

confidence: 99%

Mechanochemical Reactivity of Bottlebrush and Dendronized Polymers: Solid vs. Solution States

2021

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We explored the mechanochemical degradation of bottlebrush and dendronized polymers in solution (with ultrasonication, US) and solid states (with ball-mill grinding, BMG). Over 50 polymers were prepared with varying backbone length and arm architecture,composition, and size.With US,w ef ound that bottlebrush and dendronized polymers exhibited consistent backbone scission behavior,w hichw as related to their elongated conformations in solution. Considerably different behavior was observed with BMG,a sa rm architecture and composition had as ignificant impact on backbone scission rates.A rm scission was also observed for bottlebrush polymers in both solution and solid states,but only in the solid state for dendronized polymers.Motivated by these results,m ulti-mechanophore polymers with bottlebrush and dendronized polymer architectures were prepared and their reactivity was compared. Although dendronized polymers showed slower arm-scission, the selectivity for mechanophore activation was muchh igher.O verall, these results have important implications to the development of new mechanoresponsive materials.

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“…Seit reichlich anderthalb Dekaden versuchen Forscher, die Einwirkung von Kraft auf polymere Materialien und die damit einhergehenden Bindungsbrüche zu nutzen, 7) darunter meine Gruppe: 8,9) Wir entwickeln optische Kraftsonden, die ihre Fluoreszenzemission einschalten, wenn eine Spannung oder Dehnung in der Polymerarchitektur überschritten wird. Mit solchen Sollbruchstellen lassen sich Prozesse und Veränderungen in Materialien von der Makro-bis zur Nanoebene verfolgen.…”

Section: Kraftsonden Und Materialienunclassified

Machen, zerstören, besser machen

Göstl¹

2021

Nachr Chem

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Mechanochemical tools for polymer materials

Abstract: This review aims to provide a field guide for the implementation of mechanochemistry in synthetic polymers by summarizing the molecules, materials, and methods that have been developed in this field.

Cited by 259 publications

References 223 publications

Activation of the Catalytic Activity of Thrombin for Fibrin Formation by Ultrasound

Activation of the Catalytic Activity of Thrombin for Fibrin Formation by Ultrasound

Mechanochemical Reactivity of Bottlebrush and Dendronized Polymers: Solid vs. Solution States

Machen, zerstören, besser machen

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