Mechanochemical synthesis, characterization and antimicrobial screening of Metal (II) complexes derived from amoxicillin

Jibril, S.; Sani, S.; Kurawa, MA; Sale, Shehu

doi:10.4314/bajopas.v12i1.14

Cited by 4 publications

(6 citation statements)

References 3 publications

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“…Conductivity measurement as shown in Table 1 and performed in 1x10 Similar results were reported by [10]. The electronic spectra data is shown in Table 4 in which the ligand present three distinct absorption bands at 207nm, 208nm and 238nm attributed to n-π * , π-π * and C T which was assigned to the metal-ligand charge transfer [11]. These bands shifted to lower values in the complexes demonstrating the evidence of coordination between ligand and metal ion, as in the case of Mn (II) complexes at 215nm, 223nm, 238nm and 243nm which has been assigned to n-π * , π-π * , 5 T2g-5 T2g and 5 T2g- 5 Eg respectively, while Ni (II) complex exhibits two prominent band at 223nm and 233nm assigned to 3 A2g-3 T2g and 3 A2g-3 T1g which account for octahedral geometry [12].…”

Section: Resultssupporting

confidence: 68%

Solvent-Free Preparation and Antimicrobial Studies of Metal (Ii) Complexes Derived From Cloxacillin

Jibril¹,

Saje²,

Musa³

et al. 2023

JCSN

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The authors use an environmental friendly, solvent-free method to prepare metal (II) complexes of cloxacillin and to determine the activity of the complexes. The complexes are more active against the bacteria isolates than the free cloxacillin. The spectral studies showed the cloxacillin (ligand) as monobasic bidentate material that form a complex with metal ion through the carbonyl of amide and carboxylate groups of carboxylic acid, microanalysis results prove that the ligand to metal ratio is 2:1. The researchers recommend the use of solvent-free drugs in the manufacture of metal (II) complexes of active pharmaceutical ingredients to avoid the excessive use of solvents that cause global problems.

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Section: Resultssupporting

confidence: 68%

Solvent-Free Preparation and Antimicrobial Studies of Metal (Ii) Complexes Derived From Cloxacillin

Jibril¹,

Saje²,

Musa³

et al. 2023

JCSN

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“…The electronic spectra were recorded in 1x10 -3 ml in DMF solvent in the range of 200-700nm. The ligand showed three bands at 209nm, 227nm and 232nm which may be assigned to n-π * , π-π * and CT band transition which suggestive of none geometry [10]. The Cu (II) complexes by both methods showed the following 𝜆 max at transitions which are summarized in Table 3 as; Cu (II) complex of solution synthesis shows three bands at 233nm, 239nm and 426nm which are assigned to n-π * , π-π * and 2 Eg-T 2 g, while Cu (II) complex of solid state synthesis also shows three bands at 223nm, 231nm and 327nm respectively, these are assigned to n-π * , π-π * and 2 Eg-T 2 g also which suggests an octahedral geometry around Cu ion as reported in the literature of [14].…”

Section: Resultsmentioning

confidence: 97%

“…The plates were inverted and allowed to stand for 30mins for the extract to diffuse in to the agar after which the plates were incubated aerobically at 35 0 C for 18 hours. This was followed by measurement of zone of inhibition by the test organisms around each of the extract and standard antibiotic discs [10]. The higher the values for the complexes in both methods than the free ligand revealed the good nature of the complexes and provide evidence for the coordination as revealed by the literature of [10].…”

Section: Antimicrobial Studiesmentioning

confidence: 97%

“…This was followed by measurement of zone of inhibition by the test organisms around each of the extract and standard antibiotic discs [10]. The higher the values for the complexes in both methods than the free ligand revealed the good nature of the complexes and provide evidence for the coordination as revealed by the literature of [10]. The physical properties are shown in Table 1 by both methods.…”

Section: Antimicrobial Studiesmentioning

confidence: 98%

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Comparative Synthesis, Spectral and Antimicrobial Studies of Metal (Ii) Complexes Derived From Aspirin

Jibril¹,

Jibrin²,

Isah³

et al. 2023

JCSN

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The objective of this research work is to compare the findings of the two techniques of synthesis (solid state and solution based synthesis) in order to know whether the two results are similar or not and also to determine if the introduction of the metal ion increase or decrease the activity of the drug. From the spectral studies, it revealed that the ligand act as bidentate which coordinated to the central metal through the carbonyl of acid and ester. The elemental analysis data agreed with the proposed structure of the complexes and revealed the ratio of 2:1. Bacterial activity test shows the increase in activity from the complexes compared with the free ligand. The authors recommend the application of solid state synthesis as the method also provide the same or better result than the solution based synthesis and also the solid state method is more effective and greener synthesis.

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“…Amoxicillin Fe (II) complex did not show activity against Staphylococcus aureus and Escherichia coli. The complex with Mn (II) showed the highest antimicrobial activity against Staphylococcus aureus in all concentrations [ 142 ]. However, the biological activity of these complexes was not compared with the activity of the complexes synthesized by other synthetic methods.…”

Section: Antimicrobial Applications Of Mechanochemically-synthesized ...mentioning

confidence: 99%

Mechanochemical Synthesis of Nanoparticles for Potential Antimicrobial Applications

2023

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There is an increased interest in porous materials due to their unique properties such as high surface area, enhanced catalytic properties, and biological applications. Various solvent-based approaches have been already used to synthesize porous materials. However, the use of large volume of solvents, their toxicity, and time-consuming synthesis make this process less effective, at least in terms of principles of green chemistry. Mechanochemical synthesis is one of the effective eco-friendly alternatives to the conventional synthesis. It adopts the efficient mixing of reactants using ball milling without or with a very small volume of solvents, gives smaller size nanoparticles (NPs) and larger surface area, and facilitates their functionalization, which is highly beneficial for antimicrobial applications. A large variety of nanomaterials for different applications have already been synthesized by this method. This review emphasizes the comparison between the solvent-based and mechanochemical methods for the synthesis of mainly inorganic NPs for potential antimicrobial applications, although some metal-organic framework NPs are briefly presented too.

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Mechanochemical synthesis, characterization and antimicrobial screening of Metal (II) complexes derived from amoxicillin

Abstract: No Abstract.

Cited by 4 publications

References 3 publications

Solvent-Free Preparation and Antimicrobial Studies of Metal (Ii) Complexes Derived From Cloxacillin

Solvent-Free Preparation and Antimicrobial Studies of Metal (Ii) Complexes Derived From Cloxacillin

Comparative Synthesis, Spectral and Antimicrobial Studies of Metal (Ii) Complexes Derived From Aspirin

Mechanochemical Synthesis of Nanoparticles for Potential Antimicrobial Applications

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