Mechanochemical Interactions between Striated Muscle Cells of Jellyfish and Grafted Extracellular Matrix Can Induce and Inhibit DNA Replication and Transdifferentiation in Vitro

Schmid, Volker; Baader, Christine D.; Bucciarelli, Alessandra; Reber‐Müller, Susanne

doi:10.1006/dbio.1993.1046

Cited by 30 publications

(28 citation statements)

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“…A few cases are documented, showing that cnidarian cells apparently changed the state of differentiation (Martin and Thomas 1981;Martin 1989). Trans-differentiation into neurons of the RFamide immunoreactive type has been most convincingly proven to occur from mononucleated striated muscle cells of the medusa of Podocoryne carnea, but this was shown only for striated muscle cells dispersed by collagenase treatment (Schmid et al 1993). In Hydra, ganglionic cells convert to sensory cells while shifted during coherent tissue displacement toward the hypostome (Koizumi et al 1988).…”

Section: Discussionmentioning

confidence: 99%

Neuronal cell death during metamorphosis of Hydractina echinata (Cnidaria, Hydrozoa)

et al. 2010

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In planula larvae of the invertebrate Hydractinia echinata (Cnidaria, Hydrozoa), peptides of the GLWamide and the RFamide families are expressed in distinct subpopulations of neurons, distributed in a typical spatial pattern through the larval body. However, in the adult polyp GLWamide or RFamide-expressing cells are located at body parts that do not correspond to the prior larval regions. Since we had shown previously that during metamorphosis a large number of cells are removed by programmed cell death (PCD), we aimed to analyze whether cells of the neuropeptide-expressing larval nerve net are among those sacrificed. By immunohistochemical staining and in situ hybridization, we labeled GLWamide- and RFamide-expressing cells. Double staining of neuropeptides and degraded DNA (TUNEL analysis) identified some neurosensory cells as being apoptotic. Derangement of the cytoplasm and rapid destruction of neuropeptide precursor RNA indicated complete death of these particular sensory cells in the course of metamorphosis. Additionally, a small group of RFamide-positive sensory cells in the developing mouth region of the primary polyp could be shown to emerge by proliferation. Our results support the idea that during metamorphosis, specific parts of the larval neuronal network are subject to neurodegeneration and therefore not used for construction of the adult nerve net. Most neuronal cells of the primary polyp arise by de novo differentiation of stem cells commited to neural differentiation in embryogenesis. At least some nerve cells derive from proliferation of progenitor cells. Clarification of how the nerve net of these basal eumetazoans degenerates may add information to the understanding of neurodegeneration by apoptosis as a whole in the animal kingdom.

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Section: Discussionmentioning

confidence: 99%

Neuronal cell death during metamorphosis of Hydractina echinata (Cnidaria, Hydrozoa)

et al. 2010

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“…Isolated, mononucleated, cross-striated muscle cells of a medusa can transdifferentiate in vitro to various new cell types and even form a complex regenerate (Schmid et al, 1982(Schmid et al, , 1993Alder and Schmid, 1987;Schmid andPlickert, 1990, Schmid andReber-Müller, 1995;Yanze et al, 1999). The transdifferentiation events follow a strict pattern (Schmid, 1992).…”

Section: Stem Cell Biology In Hydractinia 529mentioning

confidence: 99%

Hydractinia, a pioneering model for stem cell biology and reprogramming somatic cells to pluripotency

Plickert¹,

Frank²,

Müller³

2012

Int. J. Dev. Biol.

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“…It serves as a skeleton, takes part in the transport and storage of nutrients (Chapman, 1966;Bouillon and Coppois, 1977;Weber and Schmid, 1985), involved in buoyancy regulation (Denton, 1963;Mackay, 1969); the elasticity of the ECM counteracts the muscle contraction that provide the propulsive swimming of the animal at medusa stage (Bouillon and Coppois, 1977;Weber and Schmid, 1985). The mesoglea also plays a key role in the control of cell migration and morphogenetic processes (Schmid, 1992;Sarras et al, 1993;Frank and Rinkevich, 1999;Shimizu et al, 2002;Kleinman et al, 2003;Schmid et al, 1993). In the ECM of the bell, a collagenous and microfibrillar fiber system forms a threedimensional meshwork.…”

Section: Introductionmentioning

confidence: 99%

A novel Aurelia aurita protein mesoglein contains DSL and ZP domains

Matveev

Shaposhnikova

Podgornaya

2007

Gene

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Mechanochemical Interactions between Striated Muscle Cells of Jellyfish and Grafted Extracellular Matrix Can Induce and Inhibit DNA Replication and Transdifferentiation in Vitro

Cited by 30 publications

References 0 publications

Neuronal cell death during metamorphosis of Hydractina echinata (Cnidaria, Hydrozoa)

Neuronal cell death during metamorphosis of Hydractina echinata (Cnidaria, Hydrozoa)

Hydractinia, a pioneering model for stem cell biology and reprogramming somatic cells to pluripotency

A novel Aurelia aurita protein mesoglein contains DSL and ZP domains

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