Mechanochemical Adhesion and Plasticity in Multifiber Hydrogel Networks

Davidson, Matthew D.; Ban, Ehsan; Schoonen, Anna C. M.; Lee, Mu‐Huan; D’Este, Matteo; Shenoy, Vivek B.; Burdick, Jason A.

doi:10.1002/adma.201905719

Cited by 50 publications

(54 citation statements)

References 39 publications

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“…[ 78 ] Recently, dynamic covalent bonds present in multifiber‐based networks allowed mechanochemical interactions among complementary fiber species upon force‐induced contact. [ 79 ] Herein, we explored this unique behavior on hybrid polysaccharide/polypeptide hydrogels for the first time, which can more closely convey the multifunctional composition of natural matrices.…”

Section: Resultsmentioning

confidence: 99%

Mechanochemical Patternable ECM‐Mimetic Hydrogels for Programmed Cell Orientation

Lavrador

Gaspar

Mano

2020

Adv Healthcare Materials

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Native human tissues are supported by a viscoelastic extracellular matrix (ECM) that can adapt its intricate network to dynamic mechanical stimuli. To recapitulate the unique ECM biofunctionality, hydrogel design is shifting from typical covalent crosslinks toward covalently adaptable networks. To pursue such properties, herein hybrid polysaccharide-polypeptide networks are designed based on dynamic covalent assembly inspired by natural ECM crosslinking processes. This is achieved through the synthesis of an amine-reactive oxidized-laminarin biopolymer that can readily crosslink with gelatin (oxLAM-Gelatin) and simultaneously allow cell encapsulation. Interestingly, the rational design of oxLAM-Gelatin hydrogels with varying aldehyde-to-amine ratios enables a refined control over crosslinking kinetics, viscoelastic properties, and degradability profile. The mechanochemical features of these hydrogels post-crosslinking offer an alternative route for imprinting any intended nano-or microtopography in ECM-mimetic matrices bearing inherent cell-adhesive motifs. Different patterns are easily paved in oxLAM-Gelatin under physiological conditions and complex topographical configurations are retained along time. Human adipose-derived mesenchymal stem cells contacting mechanically sculpted oxLAM-Gelatin hydrogels sense the underlying surface nanotopography and align parallel to the anisotropic nanoridge/nanogroove intercalating array. These findings demonstrate that covalently adaptable features in ECM-mimetic networks can be leveraged to combine surface topography and cell-adhesive motifs as they appear in natural matrices.

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Section: Resultsmentioning

confidence: 99%

Mechanochemical Patternable ECM‐Mimetic Hydrogels for Programmed Cell Orientation

Lavrador

Gaspar

Mano

2020

Adv Healthcare Materials

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“…With the increasing requirements for complex functions, homogeneous hydrogels that with uniform bulk properties show more and more limitations, while those hierarchical hydrogels containing multiple layers/ membranes show increasing advantages in terms of structural complexity and functional diversity play crucial role in many fields. [84,[359][360][361][362][363][364] In addition to the traditional photo-polymerization technique, [365,366] in recent years, several effective technology paths have been developed for the fabrication of multi-layered hydrogels, such as layer-by-layer (LBL) technique, [367][368][369][370] step-wise technique (mainly for onion-like multi-layered hydrogels), [359,361,[371][372][373][374] sequential electrospinning technique, [375][376][377][378][379][380][381] and 3D printing (additive manufacturing) technique. [382][383][384][385] Meanwhile, "Janus" structural hydrogels can be regarded as another kind of multi-layered hydrogels (Fig.…”

Section: Multi-layered Hydrogelsmentioning

confidence: 99%

Hydrogel: Diversity of Structures and Applications in Food Science

Jia

Luo

2021

Food Reviews International

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Hydrogels are a series of soft and wet materials with three dimensions of crosslinked networks. Hydrogels have attracted great attention due to their diverse functional properties, and their wide range of applications, such as in soft robots and actuators, stretched electronic devices, tissue engineering materials, controlled-release drug delivery vehicles, biomedicine materials, food science, and (bio)sensors. In general, there are four core concerns in hydrogel science, including the polymer source, structure fabrication, gel function, and gel applications. According to the logic that the "structure determines function", it is believed that rational design of structures can effectively regulate the functions and applications of hydrogels. Hence, in the current review, "structure" as the core topic will be highly regarded, and the crosslinking mechanisms and structural diversity of hydrogels are comprehensively summarized. Additionally, hydrogels also show their great application potential in food science. Hence, the current review also pays more attention to the application of hydrogels in food nutrition and health, food engineering and processing, and food safety. It is whished that this review not only serves as a reference for improving the comprehensive understanding of the structural design of hydrogels but also provides a forward-looking idea for hydrogel applications in food science.

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“…Furthermore, mechanical properties can be tuned by controlling the molecular structure of the polymers and cross-linking agents to recapitulate those of natural tissues [154][155][156]. The microstructures of hydrogels allow the exchange of nutrients and gases, which is essential for cell survival, proliferation, and differentiation [157]; therefore, given their advantages over bioinert polymers, much research has been actively exploring the applications of hydrogels in bio-robotic fields. The hydrogels used for…”

Section: Hydrogelmentioning

confidence: 99%

The emerging technology of biohybrid micro-robots: a review

2021

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In the past few decades, robotics research has witnessed an increasingly high interest in miniaturized, intelligent, and integrated robots. The imperative component of a robot is the actuator that determines its performance. Although traditional rigid drives such as motors and gas engines have shown great prevalence in most macroscale circumstances, the reduction of these drives to the millimeter or even lower scale results in a significant increase in manufacturing difficulty accompanied by a remarkable performance decline. Biohybrid robots driven by living cells can be a potential solution to overcome these drawbacks by benefiting from the intrinsic microscale self-assembly of living tissues and high energy efficiency, which, among other unprecedented properties, also feature flexibility, self-repair, and even multiple degrees of freedom. This paper systematically reviews the development of biohybrid robots. First, the development of biological flexible drivers is introduced while emphasizing on their advantages over traditional drivers. Second, up-to-date works regarding biohybrid robots are reviewed in detail from three aspects: biological driving sources, actuator materials, and structures with associated control methodologies. Finally, the potential future applications and major challenges of biohybrid robots are explored. Graphic abstract

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Mechanochemical Adhesion and Plasticity in Multifiber Hydrogel Networks

Cited by 50 publications

References 39 publications

Mechanochemical Patternable ECM‐Mimetic Hydrogels for Programmed Cell Orientation

Mechanochemical Patternable ECM‐Mimetic Hydrogels for Programmed Cell Orientation

Hydrogel: Diversity of Structures and Applications in Food Science

The emerging technology of biohybrid micro-robots: a review

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