Mechanobiology of osteoblast

Jia, Yunxian; Khan, Zarnaz; Ji, Mili; Zhong, Wenjin; Wang, Xuehao; Qian, Airong; Hu, Lifang

doi:10.1016/b978-0-323-96123-3.00007-5

Cited by 2 publications

(3 citation statements)

References 131 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 77 ] Osteoblast elongation and stretching are attributed to mechanical stimulation from the underlying implant surface features. [ 78 ] At day 3, all nanostructures favorably enhanced osteoblast spreading and attachment, with significant coverage by osteoblasts seen for N1 and least for N5. Previous studies have shown while nanopillar‐like surfaces have a higher surface area as compared to a flat surface, the cell coverage area is reduced on nanopillars at early (after 5–10 min) and late (after 24 h) times.…”

Section: Resultsmentioning

confidence: 99%

Bioinspired, Bioactive, and Bactericidal: Anodized Nanotextured Dental Implants

Chopra,

Guo,

Jayasree

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Bioinspired titanium implant nanotexturing achieved via advanced techniques such as lithography, hydrothermal and laser patterning enables modulation of cell functions toward enhanced bioactivity and antibacterial efficacy. However, such costly, multi‐step methods limit clinical translation and benchtop implant modification. For the first time, single‐step, cost‐effective, and translatable electrochemical anodization is reported to fabricate bioinspired nanopillar‐like textures on micro‐rough titanium. In‐depth surface characterization confirms the formation of novel nanostructures, namely nanoscale Spinules, Daggers, Papillae, Spikes, and Flames, exhibiting varied roughness and wettability. Next, in separate experiments, primary human osteoblasts and polymicrobial salivary biofilm are cultured on the implant substrates. Nanotextured surfaces show high protein adhesion and maintain the proliferation, adhesion, and spreading of osteoblasts. Interestingly, all nanotextures exhibit superior antibiofilm abilities compared to control surfaces. Bioactive and antibacterial implant surface nano‐texturing achieved via single‐step anodization has the potential for clinical translation as the next generation of orthopedic and dental implant surface modification.

show abstract

Section: Resultsmentioning

confidence: 99%

Bioinspired, Bioactive, and Bactericidal: Anodized Nanotextured Dental Implants

Chopra,

Guo,

Jayasree

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…The osteoblast is the primary cell in charge of bone development [8]. After passing through various stages of development, the mesenchymal stem cells (MSCs) found in bone marrow give rise to osteoblasts under the influence of various molecular factors, which mainly belong to bone morphogenic proteins (BMPs) [9].…”

Section: Osteoblastsmentioning

confidence: 99%

“…Osteoblasts are mechanically sensitive and can translate mechanical pressures into biochemical signals that affect cellular activity and gene expression. According to research, osteoblasts react to situations involving both mechanical loading and unloading [8]. Osteoblast function dysregulation is a factor in bone disorders.…”

Section: Osteoblastsmentioning

confidence: 99%

Intersecting Paths: Unraveling the Complex Journey of Cancer to Bone Metastasis

Arakil,

Akhund,

Elaasser

et al. 2024

Biomedicines

View full text Add to dashboard Cite

The phenomenon of bone metastases presents a significant challenge within the context of advanced cancer treatments, particularly pertaining to breast, prostate, and lung cancers. These metastatic occurrences stem from the dissemination of cancerous cells into the bone, thereby interrupting the equilibrium between osteoblasts and osteoclasts. Such disruption results in skeletal complications, adversely affecting patient morbidity and quality of life. This review discusses the intricate interplay between cancer cells and the bone microenvironment, positing the bone not merely as a passive recipient of metastatic cells but as an active contributor to cancer progression through its distinctive biochemical and cellular makeup. A thorough examination of bone structure and the dynamics of bone remodeling is undertaken, elucidating how metastatic cancer cells exploit these processes. This review explores the genetic and molecular pathways that underpin the onset and development of bone metastases. Particular emphasis is placed on the roles of cytokines and growth factors in facilitating osteoclastogenesis and influencing osteoblast activity. Additionally, this paper offers a meticulous critique of current diagnostic methodologies, ranging from conventional radiography to advanced molecular imaging techniques, and discusses the implications of a nuanced understanding of bone metastasis biology for therapeutic intervention. This includes the development of targeted therapies and strategies for managing bone pain and other skeletal-related events. Moreover, this review underscores the imperative of ongoing research efforts aimed at identifying novel therapeutic targets and refining management approaches for bone metastases. It advocates for a multidisciplinary strategy that integrates advancements in medical oncology and radiology with insights derived from molecular biology and genetics, to enhance prognostic outcomes and the quality of life for patients afflicted by this debilitating condition. In summary, bone metastases constitute a complex issue that demands a comprehensive and informed approach to treatment. This article contributes to the ongoing discourse by consolidating existing knowledge and identifying avenues for future investigation, with the overarching objective of ameliorating patient care in the domain of oncology.

show abstract

Mechanobiology of osteoblast

Cited by 2 publications

References 131 publications

Bioinspired, Bioactive, and Bactericidal: Anodized Nanotextured Dental Implants

Bioinspired, Bioactive, and Bactericidal: Anodized Nanotextured Dental Implants

Intersecting Paths: Unraveling the Complex Journey of Cancer to Bone Metastasis

Contact Info

Product

Resources

About