Mechanobiology in Cells and Tissues

Martino, Sabata

doi:10.3390/ijms24108564

Cited by 1 publication

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“…The mechanical properties of the PBCE and BDG50 scaffolds and films were investigated and compared. All samples were subjected to tensile measurements, knowing that cell viability and response are strictly related to the mechanical characteristics of the substrate onto which they are cultured [ 37 ]. The stress–strain curves are shown in Figure 9 , while the corresponding mechanical data (elastic modulus, E, stress at break, σ B , and deformation at break, ε B ) are listed in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Novel Nanostructured Scaffolds of Poly(butylene trans-1,4-cyclohexanedicarboxylate)-Based Copolymers with Tailored Hydrophilicity and Stiffness: Implication for Tissue Engineering Modeling

et al. 2023

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Here, we present novel biocompatible poly(butylene trans-1,4-cyclohexanedicarboxylate) (PBCE)-based random copolymer nanostructured scaffolds with tailored stiffness and hydrophilicity. The introduction of a butylene diglycolate (BDG) co-unit, containing ether oxygen atoms, along the PBCE chain remarkably improved the hydrophilicity and chain flexibility. The copolymer containing 50 mol% BDG co-units (BDG50) and the parent homopolymer (PBCE) were synthesized and processed as electrospun scaffolds and compression-molded films, added for the sake of comparison. We performed thermal, wettability, and stress–strain measures on the PBCE-derived scaffolds and films. We also conducted biocompatibility studies by evaluating the adhesion and proliferation of multipotent mesenchymal/stromal cells (hBM-MSCs) on each polymeric film and scaffold. We demonstrated that solid-state properties can be tailored by altering sample morphology besides chemical structure. Thus, scaffolds were characterized by a higher hydrophobicity and a lower elastic modulus than the corresponding films. The three-dimensional nanostructure conferred a higher adsorption protein capability to the scaffolds compared to their film counterparts. Finally, the PBCE and BDG50 scaffolds were suitable for the long-term culture of hBM-MSCs. Collectively, the PBCE homopolymer and copolymer are good candidates for tissue engineering applications.

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Section: Resultsmentioning

confidence: 99%