Mechanobiological Optimization of Scaffolds for Bone Tissue Engineering
Timothy O. Josephson,
Elise F. Morgan
Abstract:Synthetic bone graft scaffolds aim to generate new bone tissue and alleviate the limitations of autografts and allografts. To meet that aim, it is essential to have a design approach able to generate scaffold architectures that will promote bone formation. Here we present an efficient and flexible topology-varying design optimization method, the "mixed-topology" approach, that generates new designs from a set of starting structures. This approach was used with objective functions focusing on improving the scaf… Show more
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