Mechanoadaptive injectable hydrogel based on poly(γ-glutamic acid) and hyaluronic acid regulates fibroblast migration for wound healing

Yang, Rong; Huang, Jinjian; Zhang, Wenjie; Xue, Wenliang; Jiang, Yungang; Li, Sicheng; Wu, Xiuwen; Xu, Hong; Ren, Jianan; Chi, Bo

doi:10.1016/j.carbpol.2021.118607

Cited by 49 publications

(24 citation statements)

References 42 publications

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“…This means that the ADAC hydrogel was stiff, while the DAC hydrogel was soft. As reported that higher stiffness of the hydrogel favored fibroblast migration on its surface, the ADAC hydrogel was expected to be a promising wound dressing material. For a frequency sweep (Figure d), G ′ was always higher than the corresponding G ″ in the angular frequency range of 0.1–10 rad/s, illustrating that these hydrogels were structurally stable and had a solid-like elasticity.…”

Section: Resultsmentioning

confidence: 97%

Self-Healing Hyaluronic Acid Nanocomposite Hydrogels with Platelet-Rich Plasma Impregnated for Skin Regeneration

Dong

Peng

et al. 2022

ACS Nano

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The development of natural hydrogels with sufficient strength and self-healing capacity to accelerate skin wound healing is still challenging. Herein, a hyaluronic acid nanocomposite hydrogel was developed based on aldehyde-modified sodium hyaluronate (AHA), hydrazide-modified sodium hyaluronate (ADA), and aldehyde-modified cellulose nanocrystals (oxi-CNC). This hydrogel was formed in situ using dynamic acylhydrazone bonds via a double-barreled syringe. This hydrogel exhibited improved strength and excellent self-healing ability. Furthermore, platelet-rich plasma (PRP) can be loaded in the hyaluronic acid nanocomposite hydrogels (ADAC) via imine bonds formed between amino groups on PRP (e.g., fibrinogen) and aldehyde groups on AHA or oxi-CNC to promote skin wound healing synergistically. As expected, ADAC hydrogel could protect and release PRP sustainably. In animal experiments, ADAC@PRP hydrogel significantly promoted full-thickness skin wound healing through enhancing the formation of granulation tissue, facilitating collagen deposition, and accelerating re-epithelialization and neovascularization. This self-healing nanocomposite hydrogel with PRP loading appears to be a promising candidate for wound therapy.

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Section: Resultsmentioning

confidence: 97%

Self-Healing Hyaluronic Acid Nanocomposite Hydrogels with Platelet-Rich Plasma Impregnated for Skin Regeneration

Dong

Peng

et al. 2022

ACS Nano

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“…The gelation time was determined using the vial-tilting method [ 53 ]; after adding Fe 3 O 4 -CaO 2 -Hydrogel in a vial, the sol-to-gel transition of the mixture at 37 °C was determined by vial tilting every 10 s. The gelation time was recorded when the hydrogel formed and stopped flowing upon vial tilting. SEM and SEM mapping measurements were conducted by a scanning electron microscope (SEM, JSM-6700F, JEOL, Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

A Self-Supplying H2O2 Modified Nanozyme-Loaded Hydrogel for Root Canal Biofilm Eradication

Song

Liang

Zou

et al. 2022

IJMS

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The success of root canal therapy depends mainly on the complete elimination of the root canal bacterial biofilm. The validity and biocompatibility of root canal disinfectant materials are imperative for the success of root canal treatment. However, the insufficiency of the currently available root canal disinfectant materials highlights that more advanced materials are still needed. In this study, a nanozyme-loaded hydrogel (Fe3O4-CaO2-Hydrogel) was modified and analyzed as a root canal disinfectant material. Fe3O4-CaO2-Hydrogel was fabricated and examined for its release profile, biocompatibility, and antibacterial activity against E. faecalis and S. sanguis biofilms in vitro. Furthermore, its efficiency in eliminating the root canal bacterial biofilm removal in SD rat teeth was also evaluated. The results in vitro showed that Fe3O4-CaO2-Hydrogel could release reactive oxygen species (ROS). Moreover, it showed good biocompatibility, disrupting bacterial cell membranes, and inhibiting exopolysaccharide production (p < 0.0001). In addition, in vivo results showed that Fe3O4-CaO2-Hydrogel strongly scavenged on root canal biofilm infection and prevented further inflammation expansion (p < 0.05). Altogether, suggesting that Fe3O4-CaO2-Hydrogel can be used as a new effective biocompatible root canal disinfectant material. Our research provides a broad prospect for clinical root canal disinfection, even extended to other refractory infections in deep sites.

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“…[53][54][55][56] Due to the lack of adhesive action, excessive swelling, and premature degradation upon contact with tissue, the mechanical properties of HA-based hydrogels are generally poor as wound repairing materials. These issues can be addressed by chemical modification of HA to improve the cross-linking degree of networks, and the interpenetration and entanglement of the polymer chains, including catechol [57][58][59][60][61][62][63] and pyrogallol 57,64 for musselinspired catechol chemistry through hydrogen-bond interaction and metal ions coordination, aldehydes from periodate oxidation of HA 60,[65][66][67][68][69] and photoactive o-nitrobenzyl [70][71][72][73] for Schiff base reaction, methacrylate 61,62,71,[74][75][76] for photoinitiated free radical polymerization, phenylboronic acid 77,78 for glucose-sensitive dynamic borate bond with polyphenol groups, etc.…”

Section: Hyaluronic Acidmentioning

confidence: 99%

“…Polypeptides and peptides-based polymers obtained from microbes and chemical procedures have been widely used in wound healing hydrogels. Microbial polypeptides, such as g-poly(glutamic acid) (g-PGA) 25,67,142,143 and e-poly(L-lysine) (e-PL) 66,142,144 are the most commonly used representative due to their high water-absorbing ability and abundant reactive sites (amino/carboxyl group) on polymer chains. As a polycationic polymer, e-PL has broad-spectrum antibacterial activity.…”

Section: Polypeptides and Peptides-based Polymersmentioning

confidence: 99%

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

Mao

et al. 2022

J. Mater. Chem. B

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Mechanoadaptive injectable hydrogel based on poly(γ-glutamic acid) and hyaluronic acid regulates fibroblast migration for wound healing

Cited by 49 publications

References 42 publications

Self-Healing Hyaluronic Acid Nanocomposite Hydrogels with Platelet-Rich Plasma Impregnated for Skin Regeneration

Self-Healing Hyaluronic Acid Nanocomposite Hydrogels with Platelet-Rich Plasma Impregnated for Skin Regeneration

A Self-Supplying H2O2 Modified Nanozyme-Loaded Hydrogel for Root Canal Biofilm Eradication

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

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