Mechano-mediated M2 macrophage polarization and immune suppression in stiffened tumor microenvironment
Jiranuwat Sapudom,
Paul Tipay,
Jeremy CM Teo
Abstract:The tumor microenvironment (TME), which is composed of various cell types and the extracellular matrix (ECM), plays crucial roles in cancer progression and treatment outcomes. However, the impact of the mechanical properties of the ECM, specifically collagen fibril alignment and crosslinking, on macrophage behavior and polarization is less understood. To investigate this, we reconstituted 3D collagen matrices to mimic the physical characteristics of the TME. Our results demonstrated that stiffening the matrix … Show more
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