Mechanized Silica Nanoparticles Based on Pillar[5]arenes for On‐Command Cargo Release

Abstract

Mechanized silica nanoparticles, equipped with pillar[5]arene-[2]pseudorotaxane nanovalves, operate in biological media to trap cargos within their nanopores, but release them when the pH is lowered or a competitive binding agent is added. Although cargo size plays an important role in cargo loading, cargo charge-type does not appear to have any significant influence on the amount of cargo loading or its release. These findings open up the possibility of using pillar[n]arene and its derivatives for the formation of robust and dynamic nanosystems that are capable of performing useful functions.

Combinatorial nanocarrier based drug delivery approach for amalgamation of anti-tumor agents in breast cancer cells: an improved nanomedicine strategy

“…Mesoporous silica nanoparticles (MSNs) are gaining more importance as an ideal drug container than polymers, micelles and liposomes owing to a tunable aperture size, great aperture volume, superior biocompatibility, and simple functionalization against cancer cells 14 15 16 . The use of inorganic nanoparticles 17 , organic molecules 18 , and biomolecules 19 as MSN gatekeepers demonstrated well-controlled discharge performance 16 . However, the simultaneous and cascade discharge of two or more drugs is still difficult to accomplish.…”

Molecular-Scale Porous Materials Based on Pillar[n]arenes

“…45 Yang and co-workers first reported the pillar [5]arene-based mechanized MSNs for on-command cargo release activated by adjusting the pH and competitive binding ( Figure 6A). 46 Du and co-workers constructed supramolecular nanovalves by combining phosphonated pillar [5]arene 8 [5] and MSNs modified with cationic choline or pyridinium moieties ( Figure 6B). 47 Drugs can be encapsulated into the MSN pores when 8 [5] is encircling the cation stalks because of the high binding affinity of 8 [5] for these cationic moieties.…”

Turn-On Supramolecular Host-Guest Nanosystems as Theranostics for Cancer

“…As and their derivatives have recently attracted great interest owing to their unique architectures, and facile high-yielding synthesis and derivatization. 52 In recent years, P[n]As, which possess unique rigid pillar architectures, have been increasingly utilized to construct smart nanomaterials such as vesicles, 54 artificial transmembrane channels, 55 molecular machines, 56 liquid crystals, 57 porous materials, 58 and supramolecular polymers. 59…”