Mechanized azobenzene-functionalized zirconium metal-organic framework for on-command cargo release

Meng, Xiangshi; Gui, Bo; Yuan, Daqiang; Zeller, Mat­thias; Wang, Cheng

doi:10.1126/sciadv.1600480

Cited by 206 publications

(148 citation statements)

References 55 publications

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“…The optically triggered release of guest molecules from powder MOFs was also demonstrated by C. Wang et al A water‐stable UiO‐68 MOF with azobenzene side groups was used to store rhodamine B. In the pristine MOF, cyclodextrin capping hindered the release of the guest molecules.…”

Section: Metal‐organic Framework With Azobenzene Side Groups In Formmentioning

confidence: 78%

Stimuli‐Responsive Metal‐Organic Frameworks with Photoswitchable Azobenzene Side Groups

Kanj

Müller

Heinke

2017

Macromol. Rapid Commun.

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Metal‐organic frameworks (MOFs) are nanoporous, crystalline hybrid materials, which enable various functionalities by incorporating functional organic molecules. By using organic linker molecules that possess photoswitchable azobenzene side groups, the remote control over certain properties was introduced to MOFs. Different MOF materials in the form of powders and thin films have been used to demonstrate the photoswitching. The applications of these stimuli‐responsive nanoporous solids range from switching the adsorption capacity of various gases over remote‐controlled release of guest molecules to continuously tunable membrane separation of molecular mixtures. A particular focus of this review is the effect of the azobenzene photoswitching on the host‐guest interaction, enabling smart applications of the material. Steric hindrance, which may suppress the photoswitching in some MOF structures, is also discussed.

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Section: Metal‐organic Framework With Azobenzene Side Groups In Formmentioning

confidence: 78%

Stimuli‐Responsive Metal‐Organic Frameworks with Photoswitchable Azobenzene Side Groups

Kanj

Müller

Heinke

2017

Macromol. Rapid Commun.

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“…Furthermore, photoswitchable molecular scaffolds20 and gel assemblies21 were realized utilising azobenzene photoisomerization. Also, for MOFs in the form of powders or thin films, photoswitchable moieties222324 were used to demonstrate the remote-control of the MOF properties like colour25, release262728 and adsorption2930313233 of the guest molecules, in particular of CO 2 (refs 32, 33). While in most cases illumination with ultraviolet-light was needed, linker molecules that can be switched with visible light were used for the MOF preparation recently34.…”

mentioning

confidence: 99%

Tunable molecular separation by nanoporous membranes

et al. 2016

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Metal-organic frameworks offer tremendous potential for efficient separation of molecular mixtures. Different pore sizes and suitable functionalizations of the framework allow for an adjustment of the static selectivity. Here we report membranes which offer dynamic control of the selectivity by remote signals, thus enabling a continuous adjustment of the permeate flux. This is realized by assembling linkers containing photoresponsive azobenzene-side-groups into monolithic, crystalline membranes of metal-organic frameworks. The azobenzene moieties can be switched from the trans to the cis configuration and vice versa by irradiation with ultraviolet or visible light, resulting in a substantial modification of the membrane permeability and separation factor. The precise control of the cis:trans azobenzene ratio, for example, by controlled irradiation times or by simultaneous irradiation with ultraviolet and visible light, enables the continuous tuning of the separation. For hydrogen:carbon-dioxide, the separation factor of this smart membrane can be steplessly adjusted between 3 and 8.

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“…A more challenging topic in glycobiology is how to selectively capture 39 trace amounts of glycopeptides from highly complicated biosamples. To tackle this challenge, the prepared PEIg-DF was chemically immobilized onto the surface of mSiO 2 @SiO 2 @-Fe 3 O 4 microspheres using its high surface specific area 40 (204.8 m 2 g − 1 ) and magnetic features.…”

Section: Resultsmentioning

confidence: 99%

A biomimetic design for a sialylated, glycan-specific smart polymer

Chen

Wang

et al. 2018

NPG Asia Mater

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Increasing evidence has indicated that glycans and their interactions with glycan-specific binding proteins have crucial roles in most physiological processes. One emerging topic in biomaterials is the construction of smart materials capable of recognizing and responding to these valuable glycans. However, because of the complicated compositions and structures as well as the low abundances and microheterogeneity of glycans, developing glycan-responsive materials with a high sensitivity and specificity is a long-term, challenging goal. Here, we report a biomimetic polymer capable of capturing and discriminating sialo-complex-type glycans with the core Neu5Ac-Gal-GlcNAc-Man sequence, which is one of the most effective biomarkers for cancer detection. As an optimized dipeptide, L-Asp-L-Phe has a strong but differential binding affinity for N-acetyl-neuraminic acid (Neu5Ac), N-acetyl-glucosamine (GlcNAc), galactose (Gal), and mannose (Man), which are the core construction units of sialylated glycans. In addition, the L-Asp-L-Phe-grafted polyethyleneimine film displays remarkable adsorption behavior for the model sialylated glycans and can discriminate their linkage isomers, which is accompanied by significant changes in the surface morphology and stiffness. These features facilitate the highly selective capture of sialylated glycopeptides from complex protein samples using PEI-g-L-Asp-L-Phe-modified mSiO 2 @SiO 2 @Fe 3 O 4 core-shell microspheres. The mechanism analysis demonstrates that the favorable polymeric spatial structures and multiple synergetic hydrogen-bonding interactions among the dipeptides and glycan are the main driving forces, indicating a clear direction for designing glycan-specific biomaterials.

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Mechanized azobenzene-functionalized zirconium metal-organic framework for on-command cargo release

Abstract: A simple strategy to construct a stimuli-responsive mechanized zirconium metal-organic framework for on-command cargo release.

Cited by 206 publications

References 55 publications

Stimuli‐Responsive Metal‐Organic Frameworks with Photoswitchable Azobenzene Side Groups

Stimuli‐Responsive Metal‐Organic Frameworks with Photoswitchable Azobenzene Side Groups

Tunable molecular separation by nanoporous membranes

A biomimetic design for a sialylated, glycan-specific smart polymer

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