Mechanistic Study on the Effect of Solvents on Polymorphic Transformation of Aripiprazole by Solvent Property Parameters and Molecular Dynamics Simulation
Zhixin Zheng,
Xin Huang,
Na Wang
et al.
Abstract:The choice of solvent is crucial in the drug crystallization process, and the mechanism of solvent effect on the crystallization results can be conducive to the selection of solvents. In this work, the effect of solvents on the suspension crystallization process of Aripiprazole (APZ) was explored by generalized solvent property parameters and molecular dynamics simulation. Eight different crystal products of APZ (Form III, Form IV, Form V, and five solvates) were obtained after suspension crystallization in 15… Show more
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