2020
DOI: 10.3390/ijms21072470
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Mechanistic Study of Triazole Based Aminodiol Derivatives in Leukemic Cells—Crosstalk between Mitochondrial Stress-Involved Apoptosis and Autophagy

Abstract: Various derivatives that mimic ceramide structures by introducing a triazole to connect the aminodiol moiety and long alkyl chain have been synthesized and screened for their anti-leukemia activity. SPS8 stood out among the derivatives, showing cytotoxic selectivity between leukemic cell lines and human peripheral blood mononuclear cells (about ten times). DAPI nuclear staining and H&E staining revealed DNA fragmentation under the action of SPS8. SPS8 induced an increase in intracellular Ca2+ levels and mi… Show more

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(1 citation statement)
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“…The development of novel and efficient synthesis protocols for attractive heterocyclic scaffolds has become an important goal in modern organic synthesis [8,9]. Triazole/isoxazole derivatives are a class of N-heterocyclic compounds with a broad range of biological and pharmacological activities including antibacterial and anticancer properties [10][11][12][13][14]. Particularly, some isoxazole and triazole derivatives have exhibited potent cytotoxic effects against various leukemia cell lines [15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%
“…The development of novel and efficient synthesis protocols for attractive heterocyclic scaffolds has become an important goal in modern organic synthesis [8,9]. Triazole/isoxazole derivatives are a class of N-heterocyclic compounds with a broad range of biological and pharmacological activities including antibacterial and anticancer properties [10][11][12][13][14]. Particularly, some isoxazole and triazole derivatives have exhibited potent cytotoxic effects against various leukemia cell lines [15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%