Mechanistic studies of the antibiofilm activity and synergy with antibiotics of isosorbide mononitrate

Hasan, Sayeed; Albayaty, Yassamin N.; Thierry, Benjamin; Prestidge, Clive A.; Thomas, Nicky

doi:10.1016/j.ejps.2018.01.003

Cited by 9 publications

(18 citation statements)

References 35 publications

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“…• 60 mg/ml isosorbide mononitrate (ISMN) (Hasan et al 2018 ) or ISMN encapsulated in liposome (Jardeleza et al 2014 );…”

Section: Nitric Oxide As An Antibiofilm Agentmentioning

confidence: 99%

“…The performance of several other antimicrobials in P. aeruginosa biofilms, including SDS, H 2 O 2 and human β-defensin 2, was also increased in the presence of NO (Barraud et al 2006 ; Ren et al 2016 ). The remaining CFU of S. aureus biofilms was reduced by 3-log when challenged with NO+ciprofloxacin compared to the antibiotic treatment alone (Hasan et al 2018 ). Using a NTHi biofilm and PCD ciliated epithelial cells coculture model, Walker et al reported that the susceptibility of NTHi biofilms towards azithromycin was boosted by NO, despite the same NO dosage per se failed to reduce the CFU of NTHi biofilms (Walker et al 2017 ).…”

Section: Nitric Oxide As An Antibiofilm Agentmentioning

confidence: 99%

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NO donors and NO delivery methods for controlling biofilms in chronic lung infections

Cai

Zhang

Yang

2021

Appl Microbiol Biotechnol

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Nitric oxide (NO), the highly reactive radical gas, provides an attractive strategy in the control of microbial infections. NO not only exhibits bactericidal effect at high concentrations but also prevents bacterial attachment and disperses biofilms at low, nontoxic concentrations, rendering bacteria less tolerant to antibiotic treatment. The endogenously generated NO by airway epithelium in healthy populations significantly contributes to the eradication of invading pathogens. However, this pathway is often compromised in patients suffering from chronic lung infections where biofilms dominate. Thus, exogenous supplementation of NO is suggested to improve the therapeutic outcomes of these infectious diseases. Compared to previous reviews focusing on the mechanism of NO-mediated biofilm inhibition, this review explores the applications of NO for inhibiting biofilms in chronic lung infections. It discusses how abnormal levels of NO in the airways contribute to chronic infections in cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and primary ciliary dyskinesia (PCD) patients and why exogenous NO can be a promising antibiofilm strategy in clinical settings, as well as current and potential in vivo NO delivery methods. Key points • The relationship between abnormal NO levels and biofilm development in lungs • The antibiofilm property of NO and current applications in lungs • Potential NO delivery methods and research directions in the future

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“…• 60 mg/ml isosorbide mononitrate (ISMN) (Hasan et al 2018 ) or ISMN encapsulated in liposome (Jardeleza et al 2014 );…”

Section: Nitric Oxide As An Antibiofilm Agentmentioning

confidence: 99%

Section: Nitric Oxide As An Antibiofilm Agentmentioning

confidence: 99%

NO donors and NO delivery methods for controlling biofilms in chronic lung infections

Cai

Zhang

Yang

2021

Appl Microbiol Biotechnol

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“…Одним из наиболее известных нитратов, антибиопленочное действие которого достаточно изучено, является изосорбид мононитрат [24]. Sayeed Hasan и соавт.…”

Section: органические нитратыunclassified

“…Sayeed Hasan и соавт. [24] продемонстрировали, что изосорбида мононитрат вызывает диспергирование биопленки бактерий Staphylococcus aureus. Применение изосорбида мононитрата в концентрации 60 мг/мл индуцирует увеличение количества колониеобразующих единиц планктонных бактерий через 6 и 24 часа экспозиции в 3 и 5 раз соответственно, что, по мнению авторов, свидетельствует о способности изосорбида мононитрата стимулировать переход «оседлых» бактерий биопленки в планктонные формы.…”

Section: органические нитратыunclassified

Медикаментозное Влияние На Диспергирование Биопленки. Доноры Оксида Азота

Абатуров¹,

Kryuchko²

2021

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Формирование биопленки патогенными бактериальными агентами ассоциировано с рецидивирующим и хроническим течением воспалительного процесса респираторного тракта. Жизненный цикл бактериальной биопленки характеризуется наличием диспергирования и отсева патогенов в неколонизированные регионы систем макроорганизма. Монооксид азота (NO) является одним из мощных триггеров диспергирования бактериальной биопленки, усиление его продукции может инициировать как рецидив, так и Îãëÿä ë³òåðàòóðè / Review of Literature ®

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“…ISMN [ 12 ] is one of the most effective and frequently used agents for treating angina pectoris [ 13 ]. The main pharmacological effect is a relaxation of the vascular smooth muscle [ 14 ], which can effectively prevent the onset of angina [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Compound Danshen Dripping Pills with Isosorbide Mononitrate in the Treatment of Elderly Patients with Unstable Angina Pectoris

Liang

Zou

Zhang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Objective To evaluate the clinical efficacy and safety of Compound Danshen Dripping Pill (CDDP) and Isosorbide Mononitrate (ISMN) in the treatment of unstable angina pectoris (UAP) in the elderly. Materials and Methods CNKI, Wanfang, VIP, CBM, and PubMed databases were searched for appropriate articles without language limitations on keywords. RevMan 5.3 software was used to perform the meta-analysis. Results This analysis compared CDDP with ISMN of 21 randomized controlled trials (RCTs) that involved a total of 2356 patients with UAP. When the treatment lasted for four weeks, the clinical effective rate was OR = 3.97, 95% CI = 2.97, 5.30, and P < 0.00001, the ECG efficiency was OR = 3.43, 95% CI = 2.13, 5.53, and P < 0.00001, and incidence of adverse reactions was OR = 0.73, 95% CI = 0.52, 1.04, and P = 0.08 > 0.05. When the treatment lasted for eight weeks, clinical efficiency rate was OR = 4.22, 95% CI = 2.37, 3.79, and P < 0.00001, incidence of adverse reactions was OR = 0.58, 95% CI = 0.26, 1.27, and P = 0.17 > 0.05, whole blood low-cut blood viscosity was SMD = -0.61 and 95% CI -1.60, 0.38, whole blood high-cut blood viscosity was SMD = -0.38 and 95% CI -0.97, 0.21, and blood cells specific volume was SMD = -0.80 and 95% CI -2.61, 1.01. Conclusion Based on this meta-analysis, the CDDP was superior to ISMN with UAP in the elderly. However, there is still a need to further verify the clinical efficacy and safety of CDDP with more strictly designed RCTs with large sample and multiple centers in the future.

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Mechanistic studies of the antibiofilm activity and synergy with antibiotics of isosorbide mononitrate

Cited by 9 publications

References 35 publications

NO donors and NO delivery methods for controlling biofilms in chronic lung infections

NO donors and NO delivery methods for controlling biofilms in chronic lung infections

Медикаментозное Влияние На Диспергирование Биопленки. Доноры Оксида Азота

The Relationship between Compound Danshen Dripping Pills with Isosorbide Mononitrate in the Treatment of Elderly Patients with Unstable Angina Pectoris

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