Mechanistic studies of nitrite reactions with metalloproteins and models relevant to mammalian physiology

Electrochemical triggered O-atom transfer reaction in nitrocarbonyl rhenium(I) complexes: An IR spectroelectrochemical investigation

“…Regarding the reactivity of coordinated nitro ligand is interesting for the potential use as nitro based oxygen atom transfer catalysts [17,19]. Even more, the O-atom transfer reaction has been observed before for other complexes of several transition metals at room temperature and by thermal activation [9,[20][21][22][23][24].…”

“…Also, the redox ''non-innocent'' behavior of coordinated nitrosyl makes it an interesting ligand for investigation [15]. The nitrite ligand has also very important physiological properties [16,17], and recently it was proposed as a ''suspect ligand'' [18]. Then, reactivity studies in rhenium carbonyl complexes with biological relevant ligands, such as NO 2 À and NO, are fundamental.…”

Molecular structure and nitrite-bonded study on copper(II) complexes of N,N-dialkyl,N′-benzyl-ethylenediamine; synthesis, spectroscopic characterization, X-ray structure, steric effect and density functional theory calculations

“…Alternatively the nitrite can be coordinated via both oxygen atoms in a bidentate approach. These flexible coordination modes of the nitrite ion result in special attention from chemists [1][2][3][4]. Basically, the relative stability of the linkage isomers is correlated with the sigma-donating affinities of the two donor atoms of the ambidentate ligand, so that the stable isomer is formed with the stronger donor atom.…”

Mechanisms of Nitric Oxide Reactions Mediated by Biologically Relevant Metal Centers

“…However, it is important to recognize that the driving force of the reductive nitrosylation of the heme proteins and models at near neutral pH is the very great stability of the ferrous nitrosyl complexes formed under excess NO. In the absence of excess NO, the reverse reaction, namely, nitrite reduction by the ferrous complexes, is thermodynamically favored [117,123]. The nitrosyl complex of metMb has also been reported to react with the biological antioxidant glutathione GSH (in the presence of excess NO) to give Mb(NO) and S-nitrosoglutathione (GSNO) [124].…”

“…However, there are other pathways to nitrosyl complexes. For example, nitrite reduction concomitant with (formal) oxidation of the metal can lead to a metal-nitrosyl complex illustrated in (16) [114][115][116][117].…”