Abstract:The study of the mechanism of fatty acid desaturases often requires the use of synthetic probes and/or standards. In this work, a general procedure for preparing chiral fluorine-tagged dialkyl sulfoxides was developed using DAG methodology. 18-fluoro-(10S)sulfoxy-1-octadecanol, 18-fluoro-(10i?)-sulfoxy-l-octadecanol, 15-fluoro-(l 15)-sulfoxypentadecane, and 15-fluoro-(lli?)-sulfoxypentadecane were prepared. These standards were used in the determination of the stereochemistry of enzymatically produced sulfoxid… Show more
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