“…The pathophysiology of FM is now thought to be based in the central nervous system, in addition to the peripheral manifestations, and involves augmented central pain processing (i.e., allodynia and hyperalgesia) [4–10]. Although a variety of therapies have been proposed, randomized controlled trials indicate that the most effective pharmacotherapies may be the alpha‐2‐delta ligands (e.g., pregabalin) or neuroamine reuptake blockers (e.g., tricyclic/heterocyclic “antidepressants” or the so called “serotonin, norepinephrine re‐uptake inhibitors”) [7–13]. Non‐drug therapies have also been emphasized, such as patient education [7–9,11–14] and aerobic exercise [8,10,13,15,16] Mechanisms accounting for the effectiveness of aerobic conditioning are unclear, although several speculative mechanisms have been proposed [1,17–19].…”