“…In the Simcyp default compound profile, in order to describe the clinical data, the OATP Cl int,T input of hepatic uptake parameter for pravastatin was back calculated by fitting to the observed in vivo PK data. In the other studies,5, 7, 8, 9 the in vitro OATP Cl int,T data generated in the suspended hepatocytes and the sandwich cultured hepatocytes were used. Nevertheless, when the in vitro data were incorporated into the PBPK model, a scaling factor was found to be necessary in order to predict the observed pravastatin PK profile accurately.…”