Mechanistic Modelling of DNA Damage Repair by the Radiation Adaptive Response Mechanism and Its Significance

Abstract

The radiation adaptive response effect is a biophysical phenomenon responsible for the enhancement of repair processes in irradiated cells. This can be observed in dedicated radiobiological experiments, e.g., where the small priming dose of ionising radiation is given before the high challenging one (the so-called Raper–Yonezawa effect). The situation is more complicated when the whole complex system (the organism) is taken into consideration; many other mechanisms make the adaptive response weaker and—in some cases—practically insignificant. The recently published simplified Monte Carlo model of human lymphocytes irradiation by X-rays allows for the calculation of the level of repair enhancement by the adaptive response when every other cellular biological mechanism is implemented. The qualitative results show that the adaptive response phenomenon, observed with some probability on a basic level, usually blurs among other effects and becomes weaker than expected. Regardless, the radiation adaptive response is still an important biophysical effect which needs to be taken into consideration in low-dose radiobiological studies.

Health Effects of Ionizing Radiation on the Human Body

“…Based on the studies, it was found that the strongest radioadaptation and the weakest cellular radiosensitivity correlate with each other [44]. The phenomenon of radiation adaptive response is, therefore, important for the recovery of irradiated cells and should be taken into account in radiobiological studies at low doses [45]. High doses of ionizing radiation are often used as a therapeutic strategy to destroy malignant cells (cancer cells).…”