Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma

Guerrero, Silvia Cabrera; Panettieri, Reynold A.; Rastogi, Deepa

doi:10.1007/s40272-022-00554-7

Cited by 4 publications

(3 citation statements)

References 160 publications

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“…In addition, long-chain free fatty acids, which are chronically elevated in obesity, directly activate the inflammasome in airway smooth muscle cells, where they activate the free fatty acid receptor 1 (FFAR1). This leads to activation of phospholipase C and extracellular signal regulated kinase signalling cascade, resulting in intracellular calcium deposition and consequent bronchoconstriction, as well as airway smooth muscle cell proliferation, both aggravating asthma symptoms [33][34][35][36].…”

Section: Molecular Backgroundmentioning

confidence: 99%

Obesity and Insulin Resistance in Asthma Pathogenesis and Clinical Outcomes

Škrgat,

Harlander,

Janić

2024

Biomedicines

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Common inflammatory ground links obesity, insulin resistance, and asthma. As recognition of their interplay, one worsening the natural course of the other, is recognised, questions remain about how to adequately address them altogether to improve clinical outcomes. The present manuscript sheds light on the problem, describing possible pathophysiological links, clinical views, and therapeutic challenges, raising questions about what remains to be done, and calling for multidisciplinary treatment of these patients to detect diseases early and adequately address them before they become full-blown and deteriorate their health and quality of life.

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Section: Molecular Backgroundmentioning

confidence: 99%

Obesity and Insulin Resistance in Asthma Pathogenesis and Clinical Outcomes

Škrgat,

Harlander,

Janić

2024

Biomedicines

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“…Lateonset obesity-associated asthma is seldom associated with high eosinophilia; therefore, new biologics (such as anti-IgE: omalizumab, and anti-eosinophils: mepolizumab, reslizumab and benralizumab) do not show significant efficacy in the treatment of this group of patients [7,18]. Clinical trials on the use of an anti-interleukin antibody, tocilizumab, in the treatment of obesity-related asthma are ongoing [29]. Vitamin D supplementation is considered an adjuvant treatment [10,12].…”

Section: Managementmentioning

confidence: 99%

Obesity and Selected Allergic and Immunological Diseases—Etiopathogenesis, Course and Management

Morąg,

Kozubek,

Gomułka

2023

Nutrients

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Obesity is a global problem. It affects every age group and is associated with many negative health effects. As an example, there is a relationship between obesity and allergic and immunological diseases, such as asthma, psoriasis, food allergies, allergic rhinitis and atopic dermatitis. Obesity undeniably affects their development. In addition, it causes adverse changes in the course and response to therapy in relation to patients without excessive body weight. The treatment of diseases associated with obesity is difficult; drugs are less effective and must be used in higher doses, and their use in patients with obesity is often associated with higher risks. The main form of treatment of all obesity-related diseases is a change in eating habits and increased physical activity, which leads to a decrease in body fat mass. The positive effect of reducing BMI has been confirmed in many independent studies. This paper reviews various types of research documents published since 2019. It aims to systematize the latest knowledge and highlight the need for further research for effective and sustainable treatment options for obesity, its complications and obesity-related diseases.

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“…Asthma is a chronic airway disease with various particular clinical phenotypes and complex pathophysiological mechanisms [ 1 , 2 ]. Nowadays, asthma associated with obesity is classified as a distinct, most severe phenotype which is not easy to control and less responsive to standard asthma medication [ 3 , 4 , 5 ]. Obesity is an independent risk factor for the pathogenesis of asthma, and it has a significant impact on asthma incidence and manifestations [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

1-O-alkyl-glycerols from Squid Berryteuthis magister Reduce Inflammation and Modify Fatty Acid and Plasmalogen Metabolism in Asthma Associated with Obesity

et al. 2023

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Asthma associated with obesity is considered the most severe phenotype and can be challenging to manage with standard medications. Marine-derived 1-O-alkyl-glycerols (AGs), as precursors for plasmalogen synthesis, have high biological activity, making them a promising substance for pharmacology. This study aimed to investigate the effect of AGs from squid Berryteuthis magister on lung function, fatty acid and plasmalogen levels, and cytokine and adipokine production in obese patients with asthma. The investigational trial included 19 patients with mild asthma associated with obesity who received 0.4 g of AGs daily for three months in addition to their standard treatment. The effects of AGs were evaluated at one and three months of treatment. The results of the study demonstrated that intake of AGs increased the FEV1 and FEV1/VC ratios, and significantly decreased the ACQ score in 17 of the 19 patients after three months of treatment. The intake of AGs increased concentration of plasmalogen and n–3 PUFA in plasma, and modified leptin/adiponectin production by adipose tissue. The supplementation of AGs decreased the plasma levels of inflammatory cytokines (TNF-α, IL-4, and IL-17a), and oxylipins (TXB2 and LTB4), suggesting an anti-inflammatory property of AGs. In conclusion, 1-O-alkyl-glycerols could be a promising dietary supplement for improving pulmonary function and reducing inflammation in obese asthma patients, and a natural source for plasmalogen synthesis. The study highlighted that the beneficial effects of AG consumption can be observed after one month of treatment, with gradual improvement after three months of supplementation.

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Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma

Cited by 4 publications

References 160 publications

Obesity and Insulin Resistance in Asthma Pathogenesis and Clinical Outcomes

Obesity and Insulin Resistance in Asthma Pathogenesis and Clinical Outcomes

Obesity and Selected Allergic and Immunological Diseases—Etiopathogenesis, Course and Management

1-O-alkyl-glycerols from Squid Berryteuthis magister Reduce Inflammation and Modify Fatty Acid and Plasmalogen Metabolism in Asthma Associated with Obesity

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